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Vincenzo Rampoldi
Santi Trimarchi
Kim A. Eagle
Jae K. Oh
Truls Myrmel
Thoralf M. Sundt, III
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Ann Thorac Surg 2007;83:55-61
© 2007 The Society of Thoracic Surgeons

Original Articles: Cardiovascular

Simple Risk Models to Predict Surgical Mortality in Acute Type A Aortic Dissection: The International Registry of Acute Aortic Dissection Score

Vincenzo Rampoldi, MDa, Santi Trimarchi, MDa,*, Kim A. Eagle, MDb, Christoph A. Nienaber, MDc, Jae K. Oh, MDd, Eduardo Bossone, MDe, Truls Myrmel, MDf, Giuseppe M. Sangiorgi, MDa, Carlo De Vincentiis, MDa, Jeanna V. Cooper, MSb, Jianming Fang, MD, MSb, Dean Smith, PhDb, Thomas Tsai, MDb, Arun Raghupathy, MDb, Rossella Fattori, MDg, Udo Sechtem, MDh, Michael G. Deeb, MDb, Thoralf M. Sundt, III, MDd, Eric M. Isselbacher, MDi International Registry of Acute Aortic Dissection (IRAD) Investigators

a Cardiovascular Center "E. Malan," Policlinico S. Donato, S. Donato Milanese, Italy
b University of Michigan, Coordinating Center for IRAD, Ann Arbor, Michigan
c University of Rostock, Rostock, Germany
d Mayo Clinic, Rochester, Minnesota
e National Research Council, Lecce, Italy
f Tromsø University Hospital, Tromsø, Norway
g University Hospital S. Orsola, Bologna, Italy
h Robert-Bosch Krankenhaus, Stuttgart, Germany
i Massachusetts General Hospital, Boston, Massachusetts

Accepted for publication August 2, 2006.

* Address correspondence to Dr Trimarchi, Cardiovascular Center "E. Malan," Policlinico S. Donato, via Morandi 30, 20097 S. Donato Milanese, Italy (Email: satrimarchi{at}yahoo.it).

BACKGROUND: Surgical mortality for acute type A aortic dissection is frequently related to preoperative clinical conditions. We report a predictive score to identify risk of death that may be helpful to assist surgeons who are considering whether to proceed with surgical correction in the case of patients in extreme clinical risk.

METHODS: Surgical outcome of 682 patients enrolled in the International Registry of Acute Aortic Dissection from 1996 to 2003 was analyzed. Two different models were used. The initial model included only preoperative variables such as demographics, history, symptoms, signs, and diagnostic methods (model 1). The second model also tested intraoperative hemodynamic and surgical variables (model 2). A bedside risk prediction tool to predict operative mortality in individual patients was developed.

RESULTS: The overall in-hospital surgical mortality was 23.9%. Independent preoperative predictors of mortality in model 1 were age greater than 70 years, prior cardiac surgery, hypotension (systolic blood pressure less than 100 mm Hg) or shock at presentation, migrating pain, cardiac tamponade, any pulse deficit, and electrocardiogram with findings of myocardial ischemia or infarction. In model 2, other predictors of surgical death were intraoperative hypotension, a right ventricle dysfunction at surgery, and a necessity to perform coronary revascularization. An independent predictor for favorable surgical outcome was right hemiarch replacement.

CONCLUSIONS: Surgery in unstable patients with acute type A aortic dissection can be highly unsuccessful. The International Registry of Acute Aortic Dissection risk models predict in-hospital mortality using a multivariable risk prediction tool, useful for surgeons and patients as they consider their surgical risk and the pros and cons of embarking on high-risk surgery.




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