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Right arrow Lung - cancer

Ann Thorac Surg 2006;82:2004-2009
© 2006 The Society of Thoracic Surgeons

Original Articles: General Thoracic

Retrospective Analysis of the Clinical Performance of Anterior Mediastinotomy

Patrik Nechala, MD*, Andrew J. Graham, MD, Sean D. McFadden, MD, Sean C. Grondin, MD, Gary Gelfand, MD

Division of Thoracic Surgery, Department of Surgery, Foothills Medical Centre, University of Calgary, Calgary, Alberta, Canada

Accepted for publication June 9, 2006.

* Address correspondence to Dr Nechala, Room G33, Foothills Medical Centre, 1403-29th St NW, Calgary, Alberta T2N 2T9, Canada (Email: pnechala{at}yahoo.com).

BACKGROUND: Accurate staging of patients with lung cancer is imperative in generating an appropriate treatment strategy. This study examined the clinical performance of anterior mediastinotomy in staging patients with suspected left upper lobe non-small cell lung cancer.

METHODS: This study was designed as a retrospective cohort. All patients with suspected left upper lobe cancer and otherwise normal computed tomography scan results were eligible. Patients with clinically unresectable disease (advanced disease or not fit for surgery) were excluded. After exclusions, 151 patients were stratified into two groups: 117 patients had cervical and anterior mediastinotomy as part of preoperative staging, and 34 had cervical mediastinoscopy only. The primary outcome was rate of preventable thoracotomy defined as thoracotomy during which either metastases to aortopulmonary or paraaortic lymph nodes, or mediastinal invasion was identified.

RESULTS: The rate of preventable thoracotomy for the anterior mediastinotomy arm was 4 (3.4%) of 117, compared with 1 (2.9%) of 34 for cervical mediastinoscopy-only arm (p = 0.99). The rate of morbidity in the anterior mediastinotomy arm was 8 (6.8%) of 117, compared with 2 (5.8%) of 34 for the cervical mediastinoscopy-only arm (p = 0.99). Anterior mediastinotomy patients stayed in hospital 1 day longer (p = 0.008). Anterior mediastinotomy was successful at harvesting one or more lymph nodes in 67% of patients. Five patients (4.3%) who underwent anterior mediastinotomy were spared a thoracotomy by identification of metastases to aortopulmonary lymph nodes.

CONCLUSIONS: In patients with suspected left upper lobe lung cancer and otherwise normal computed tomography scan results, anterior mediastinotomy does not significantly reduce the rate of preventable thoracotomy.






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