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Ann Thorac Surg 2006;82:e33-e34
© 2006 The Society of Thoracic Surgeons


Case Reports

Intracoronary Infusion of Levosimendan to Treat Postpericardiotomy Heart Failure

Philippe-Primo Caimmi, MD, MSa,*, Elena Grossini, MD, PhDb, Claudio Molinari, MD, PhDb, Giovanni Vacca, MDb, Giovanni Teodori, MDa

a Department of Cardiac Surgery, Ospedale Maggiore della Carità, School of Medicine, University of East Piedmont "A. Avogadro," Novara, Italy
b Department of Experimental and Clinical Medicine, University of East Piedmont "A. Avogadro," Novara, Italy

Accepted for publication June 22, 2006.

* Address correspondence to Dr Caimmi, Department of Cardiac Surgery, Ospedale Maggiore della Carità, School of Medicine, University of East Piedmont, Baluardo M. D'Azeglio n.5, 28100 Novara, Italy. (Email: philippe.caimmi{at}med.unipmn.it).

Systemic hypotension limits the intravenous use of levosimendan, particularly in coronary disease. Published reports show that the intracoronary administration of levosimendan in animal models causes an increase of coronary blood flow without systemic hypotension. In this case report, the intracoronary administration of levosimendan bolus in a 74-year-old man with postpericardiotomy heart failure elicited beneficial cardiac effects, increasing both systolic and diastolic functions and blood flow in all of the grafts. No changes of heart rate and systemic arterial blood pressure were observed.







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