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Ann Thorac Surg 2006;82:1906-1908
© 2006 The Society of Thoracic Surgeons

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Case Reports

Treatment of Mediastinal Immature Teratoma in a Child With Precocious Puberty and Klinefelter's Syndrome

^a Department of Surgery, National Taiwan University Hospital, National Taiwan University, College of Medicine, Taipei, Taiwan
^b Department of Pathology, National Taiwan University Hospital, National Taiwan University, College of Medicine, Taipei, Taiwan
^c Department of Pediatry, National Taiwan University Hospital, National Taiwan University, College of Medicine, Taipei, Taiwan
^d Department of Surgery and Traumatology, National Taiwan University Hospital, National Taiwan University, College of Medicine, Taipei, Taiwan

Accepted for publication March 27, 2006.

^_* Address correspondence to Dr Lee, Department of Surgery, No. 7, Jhongshan S Rd, Jhongjheng District, Taipei City, R.O.C. 100 Taiwan. (Email: wuj{at}ha.mc.ntu.edu.tw).

Teratoma is the most common germ cell tumor, which can be divided into the mature and the immature histologically. Concurrent Klinefelter's syndrome may be overlooked in a patient with a germ cell tumor. This is because the tumor that secrets alpha-fetoprotein and beta human chorionic gonadotropin can mimic puberty in a patient with Klinefelter's syndrome, masking the usual clinical signs. In reviewing the literature on the subject, the role of neoadjuvant and adjuvant chemotherapy remains ill-defined for the immature teratoma. Age-dependent prognosis seems to demonstrate that children with immature teratomas have a better outcome. We share the experience of treating a child with immature teratoma with surgical excision alone, and it ended in a local recurrence.

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