ATS
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Personal Folders
Right arrow Download to citation manager
Right arrow Author home page(s):
Motohiro Nishimura
Kazuhiro Ito
Right arrow Permission Requests
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Nishimura, M.
Right arrow Articles by Shimada, J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Nishimura, M.
Right arrow Articles by Shimada, J.
Related Collections
Right arrow Mediastinum

Ann Thorac Surg 2006;82:1904-1906
© 2006 The Society of Thoracic Surgeons

Case Reports

Autocrine Growth by Granulocyte Colony-Stimulating Factor in Malignant Mesothelioma

Motohiro Nishimura, MD, PhDa, Kyoko Itoh, MD, PhDb, Kazuhiro Ito, MD, PhDa, Masashi Yanada, MDa, Kunihiko Terauchi, MDa, Shinji Fushiki, MD, PhDb, Junichi Shimada, MD, PhDa,*

a Department of Thoracic Surgery, Kyoto Prefectural University of Medicine, Kyoto, Japan
b Department of Pathology and Applied Neurobiology, Kyoto Prefectural University of Medicine, Kyoto, Japan

Accepted for publication February 2, 2006.

* Address correspondence to Dr Shimada, Kajii-cho 465, Kamigyo-ku, Kyoto, 602-8566 Japan. (Email: shimajun{at}beige.plala.or.jp).

We report the first case of a malignant mesothelioma expressing not only granulocyte-colony stimulating factor (G-CSF), but also its receptor. A 59-year-old male carpenter underwent a panpleuropneumonectomy, but the tumor relapsed and spread rapidly, accompanied by leukocytosis. The white blood cell count reached 147,000/mm3 (96.2% neutrophils), and the concentration of serum G-CSF was 77 pg/mL. An autopsy demonstrated that some of the tumor cells produced G-CSF, but more tumor cells and endothelial cells in the tumor expressed G-CSF receptor. It was hypothesized that an autocrine loop involving G-CSF and the G-CSF receptor greatly accelerated the tumor growth.






HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
ANN THORAC SURG ASIAN CARDIOVASC THORAC ANN EUR J CARDIOTHORAC SURG
J THORAC CARDIOVASC SURG ICVTS ALL CTSNet JOURNALS
Copyright © 2006 by The Society of Thoracic Surgeons.