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David B. Meyer
Guillermo Zamora
Sarah Tabbutt
Peter J. Gruber
J. William Gaynor
Thomas L. Spray
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Ann Thorac Surg 2006;82:1611-1620
© 2006 The Society of Thoracic Surgeons


Original Articles: Cardiovascular

Outcomes of the Fontan Procedure Using Cardiopulmonary Bypass with Aortic Cross-Clamping

David B. Meyer, MDa, Guillermo Zamora, MDb, Gil Wernovsky, MDb, Richard F. Ittenbach, PhDb, Paul R. Gallagher, MAb, Sarah Tabbutt, MD, PhDb, Peter J. Gruber, MD, PhDb, Susan C. Nicolson, MDb, J. William Gaynor, MDb,*, Thomas L. Spray, MDb

a Department of Cardiothoracic Surgery, New York University, New York, New York
b Divisions of Cardiology, Cardiac Anesthesiology, Biostatistics and Data Management Core, and Cardiothoracic Surgery, The Cardiac Center at The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania

Accepted for publication May 22, 2006.

* Address correspondence to Dr Gaynor, Department of Cardiothoracic Surgery, The Children's Hospital of Philadelphia, 34th St and Civic Center Blvd, Suite 8527, Philadelphia, PA 19104 (Email: gaynor{at}email.chop.edu).

Presented at the Forty-second Annual Meeting of The Society of Thoracic Surgeons, Chicago, IL, Jan 30–Feb 2, 2006.

BACKGROUND: Avoidance of cardiopulmonary bypass (CPB) and aortic cross-clamping during the Fontan procedure has been advocated to improve outcomes. We continue to use CPB with aortic cross-clamping for the Fontan procedure.

METHODS: We performed a review of patients undergoing the Fontan procedure between January 1, 2000 and December 31, 2004.

RESULTS: The Fontan procedure was performed in 160 patients. The median age was 2.2 years (range, 1.0 to 29.1 years). Hypoplastic left heart syndrome or a variant was present in 114 patients (71%), and heterotaxy was present in 19 (12%). CPB and modified ultrafiltration were used in all patients. Aortic cross-clamping was used in 154 (96%) of 160 patients and deep hypothermic circulatory arrest (DHCA) in 132 (83%). A lateral tunnel Fontan was performed in 69 patients (43%) and an extracardiac Fontan in 91 (57%). A fenestration was created in 144 patients (90%). Two patients died. Freedom from death or takedown was 98% (157/160). Median duration of pleural drainage was 2 days (range, 1 to 44 days) and was more than 14 days in 16 patients. Median duration of hospitalization was 6 days (range, 3 to 55 days). The small number of deaths precluded assessment of risk factors for mortality. By multivariable analysis, risk factors for pleural drainage longer than 3 days were extracardiac connection (p < 0.001) and increasing mean pulmonary artery pressure before the Fontan procedure (p = 0.033). By multivariable analysis, risk factors for hospitalization for more than 7 days were extracardiac connection (p = 0.003), increasing duration of total support (CPB and DHCA, p = 0.027), and decreasing systemic oxygen saturation before the Fontan procedure (p = 0.048).

CONCLUSIONS: The Fontan procedure can be performed using CPB and aortic cross-clamping with low morbidity and mortality.




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