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Ann Thorac Surg 2006;82:1549-1558
© 2006 The Society of Thoracic Surgeons

Reviews

Repair of the Damaged Heart by Bone Marrow Cells: From Experimental Evidence to Clinical Hope

Keng-Leong Ang, MRCS, Lincoln Takura Shenje, MBChB(Hons), MS, Lakshmi Srinivasan, FRCS, Manuel Galiñanes, MD, PhD*

Cardiac Surgery Unit, Department of Cardiovascular Sciences, University of Leicester, Glenfield Hospital, Clinical Science Wing, Leicester, United Kingdom

* Address correspondence to Dr Galiñanes, Cardiac Surgery Unit, Department of Cardiovascular Sciences, University of Leicester, Glenfield Hospital, Groby Rd, Leicester LE3 9QP, United Kingdom (Email: mg50{at}le.ac.uk).

Heart failure remains the leading cause of death in developed countries in spite of improvements in medical and surgical treatments. However, recent observations in experimental studies that bone marrow cells may repair cardiac tissue have offered renewed hopes for the treatment of heart failure. This optimism is further supported by encouraging results from some clinical trials, although the degree of benefits, the underlying mechanisms, and the cell types involved remain to be elucidated. This review summarizes the relevant experimental and clinical studies supporting the use of bone marrow cells in myocardial repair, as well as the controversies and challenges encountered.






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Copyright © 2006 by The Society of Thoracic Surgeons.