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Right arrow Transplantation - heart

Ann Thorac Surg 2006;82:1529-1531
© 2006 The Society of Thoracic Surgeons

Case Reports

Levosimendan Reversing Low Output Syndrome After Heart Transplantation

Liisa M. Petäjä, MDa,*, Jorma T. Sipponen, MD, PhDb, Pekka J. Hämmäinen, MD, PhDb, Heidi I. Eriksson, MD, PhDa, Markku T. Salmenperä, MD, PhDa, Raili T. Suojaranta-Ylinen, MD, PhDa

a Department of Anesthesiology and Intensive Care Medicine, Helsinki University Hospital, Helsinki, Finland
b Department of Cardiothoracic Surgery, Helsinki University Hospital, Helsinki, Finland

Accepted for publication February 9, 2006.

* Address correspondence to Dr Petäjä, Department of Anesthesiology and Intensive Care Medicine, PL 340, 00029 HUS, Finland. (Email: liisa.petaja{at}hus.fi).

After heart transplantation primary graft failure is a major cause of early mortality. Treatment options include inotropes and mechanical assist devices. Developing better methods would impact on patients' short- and long-term survival. We present a case of primary graft failure manifested as cardiogenic shock unresponsive to catecholamines and a phosphodiesterase inhibitor. Reversal of low output syndrome was achieved with a new type of inotropic agent, levosimendan, leading to the later complete recovery.




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H. I. Eriksson, J. R. Jalonen, L. O. Heikkinen, M. Kivikko, M. Laine, K. A. Leino, A. H. Kuitunen, K. T. Kuttila, T. K. Perakyla, T. Sarapohja, et al.
Levosimendan Facilitates Weaning From Cardiopulmonary Bypass in Patients Undergoing Coronary Artery Bypass Grafting With Impaired Left Ventricular Function
Ann. Thorac. Surg., February 1, 2009; 87(2): 448 - 454.
[Abstract] [Full Text] [PDF]


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