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Davide Pacini
Fabrizio Settepani
Ruggero De Paulis
Antonino Loforte
Saverio Nardella
Roberto Gallotti
Luigi Chiariello
Roberto Di Bartolomeo
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Ann Thorac Surg 2006;82:865-872
© 2006 The Society of Thoracic Surgeons

Original article: Cardiovascular

Early Results of Valve-Sparing Reimplantation Procedure Using the Valsalva Conduit: A Multicenter Study

Davide Pacini, MDa,*, Fabrizio Settepani, MDb, Ruggero De Paulis, MDc, Antonino Loforte, MDa, Saverio Nardella, MDc, Diego Ornaghi, MDb, Roberto Gallotti, MDb, Luigi Chiariello, MDc, Roberto Di Bartolomeo, MDa

a Cardiac Surgery Department, S. Orsola-Malpighi Hospital, University of Bologna, Bologna
b Cardiac Surgery Department, Istituto Clinico Humanitas, Rozzano
c Cardiac Surgery Department, Tor Vergata University, Rome, Italy

Accepted for publication April 3, 2006.

* Address correspondence to Dr Pacini, c/o Unità Operativa di Cardiochirurgia, Università degli studi di Bologna, Policlinico S. Orsola, Via Massarenti 9, Bologna 40138, Italy (Email: dpacini{at}hotmail.com).

Presented at the Forty-second Annual Meeting of The Society of Thoracic Surgeons, Chicago, IL, Jan 30–Feb 1, 2006.

BACKGROUND: This study evaluates the midterm clinical results of valve-preserving aortic root reconstruction by means of a modified conduit incorporating sinuses of Valsalva.

METHODS: During a 5-year period, 151 patients with aneurysm of the aortic root underwent a reimplantation type of valve-sparing procedure using the Gelweave Valsalva prosthesis that incorporates sinuses of Valsalva. There were 121 males (80.1%), and the mean age was 56.4 ± 14.4 years (range, 14 to 83). Fourteen percent of the patients had Marfan syndrome and 8.6% had bicuspid aortic valve. Seven patients (4.6%) suffered from acute aortic dissection. Aortic replacement was extended to the arch in 14 patients (9.3%). Sixteen patients (10.6%) had associated cusp repair.

RESULTS: In-hospital mortality was 3.3%, and it was significantly higher among patients operated on for acute dissection (p = 0.001) and in symptomatic patients (III–IV New York Heart Association class; p = 0.021). Follow-up (mean, 18 months; range, 1 to 60) was 100% complete. There were 2 late deaths. Ten patients (6.8%) had 3 to 4+ aortic regurgitation, and 8 of these required late aortic valve replacement. Cusp repair was associated with a high incidence of late aortic valve replacement (p = 0.005). At 5 years, freedom from aortic valve replacement and freedom from grade 3 to 4 aortic insufficiency was 90.8% ± 3.3% and 88.7% ± 3.6%, respectively.

CONCLUSIONS: The reimplantation valve-sparing procedure with the Gelweave Valsalva prosthesis provides satisfactory results for patients with aortic root aneurysm. Aortic cusp repair may lead to late aortic insufficiency. Proper leaflet evaluation is of paramount importance in preventing residual valve regurgitation.




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