HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Personal Folders Download to citation manager Author home page(s): Tim Attmann Andreas Boening Jochen Cremer Georg Lutter Permission Requests Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Attmann, T. Articles by Lutter, G. Search for Related Content PubMed PubMed Citation Articles by Attmann, T. Articles by Lutter, G. Related Collections Valve disease

Ann Thorac Surg 2006;82:708-713
© 2006 The Society of Thoracic Surgeons

---

New technology

Percutaneous Pulmonary Valve Replacement: 3-Month Evaluation of Self-Expanding Valved Stents

^a Department of Cardiovascular Surgery, Christian-Albrechts-University of Kiel, School of Medicine, Kiel, Germany
^b Department of Radiology, Christian-Albrechts-University of Kiel, School of Medicine, Kiel, Germany

Accepted for publication January 26, 2006.

^_* Address correspondence to Dr Lutter, Department of Cardiovascular Surgery, Christian-Albrechts-University of Kiel, School of Medicine, Arnold-Heller-Str. 7, Kiel, 24105 Germany (Email: lutter{at}kielheart.uni-kiel.de).

PURPOSE: In a recent study our group established an acute animal model of percutaneous pulmonary valve replacement using self-expanding nitinol stents. The present study was performed to evaluate these valved stents over a 3-month period.

DESCRIPTION: Bovine jugular xenografts were sutured into nitinol stents. Transfemoral implantation in the pulmonary position using a modified commercially available application device (with a 22-French outer diameter) was evaluated in 9 sheep.

EVALUATION: Two sheep died shortly after successful valved stent implantation due to internal venous hemorrhage. Another 1 sheep died 2.5 months after the procedure due to vegetations on the neovalve leading to subtotal stenosis. All other animals survived the 3-month study time (n = 6). An orthotopic pulmonary valved stent position was achieved in 4 animals and a supravalvular position in 1. During the deployment procedure, rhythm disturbances occurred in all animals, and mean arterial blood pressure dropped from 83.9 ± 26.0 mm Hg to 68.3 ± 22.3 mm Hg (p = 0.006) (n = 5). The peak-to-peak transvalvular gradient was 5.1 ± 4.0 mm Hg initially (n = 5), and 3.6 ± 1.6 mm Hg at follow-up (n = 5). Three-month angiographic and echocardiographic follow-up confirmed competent neovalves without paravalvular leakages.

CONCLUSIONS: After 3 months of implantation, percutaneously implanted memory nitinol valved stents demonstrated good function in the sheep.

This article has been cited by other articles:

				G.-J. Zong, Y. Bai, H.-B. Jiang, W.-P. Li, H. Wu, X.-X. Zhao, and Y.-W. Qin Use of a novel valve stent for transcatheter pulmonary valve replacement: An animal study. J. Thorac. Cardiovasc. Surg., June 1, 2009; 137(6): 1363 - 1369. [Abstract] [Full Text] [PDF]

				G.-W. Meng, J.-Y. Zhou, Y. Tang, Z.-K. Ye, Y. Zhang, G.-M. Liu, and S.-S. Hu Off-Pump Pulmonary Valve Implantation of a Valved Stent With an Anchoring Mechanism. Ann. Thorac. Surg., February 1, 2009; 87(2): 597 - 601. [Abstract] [Full Text] [PDF]

				G. Lutter and J. Cremer Invited commentary. Ann. Thorac. Surg., February 1, 2009; 87(2): 601 - 602. [Full Text] [PDF]

				M. J. Antunes Off-pump aortic valve replacement with catheter-mounted valved stents.: Is the future already here? Eur. J. Cardiothorac. Surg., January 1, 2007; 31(1): 1 - 3. [Full Text] [PDF]

				T. A. Vassiliades Jr Invited commentary Ann. Thorac. Surg., August 1, 2006; 82(2): 713 - 714. [Full Text] [PDF]