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Ann Thorac Surg 2006;82:338-340
© 2006 The Society of Thoracic Surgeons

Case report

Treatment of Cavitary Pulmonary Zygomycosis With Surgical Resection and Posaconazole

Subroto Paul, MD a , Francisco M. Marty, MD b , Yolonda L. Colson, MD, PhD a , *

a Division of Thoracic Surgery, Department of Medicine, Brigham & Women's Hospital, Boston, Massachusetts
b Department of Surgery and Division of Infectious Disease, Department of Medicine, Brigham & Women's Hospital, Boston, Massachusetts

Accepted for publication September 1, 2005.

* Address correspondence to Dr Colson, Brigham and Women's Hospital, Division of Thoracic Surgery, 75 Francis St, Boston, MA 02115 (Email: ycolson{at}partners.org).

We describe a 57-year-old woman with acute lymphoblastic leukemia who had a cavitary lesion develop in the right upper lobe caused by Cunninghamella bertholletiae, a zygomycete. The infection was resistant to both high-dose liposomal amphotericin B and voriconazole. The current report demonstrates successful treatment, even in the setting of subsequent bone marrow transplantation and immunosuppression, using a combination of surgical resection and posaconazole therapy.






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