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Ann Thorac Surg 2006;82:243-248
© 2006 The Society of Thoracic Surgeons

Original article: General thoracic

Expression of Nuclear Factor-{kappa}B and Its Clinical Significance in Nonsmall-Cell Lung Cancer

Zhenfa Zhang, MD a , Jianqun Ma, MD b , Ni Li, PhD c , Nan Sun, MD d , Changli Wang, BM a , *

a Department of Lung Cancer, Affiliated Cancer Hospital, Tian Jin Medical University, Tian Jin, China
b Department of Thoracic Surgery, Affiliated Tumor Hospital, Ha Er Bin Medical University, Ha Er Bin, China
c Department of Epidemiology, China Medical University, Shen Yang, China
d Department of Thoracic Surgery, Tumor Hospital of Liao Ning Province, Shen Yang, China

Accepted for publication January 10, 2006.

* Address correspondence to Dr Wang, Department of Lung Cancer, Affiliated Cancer Hospital, Tian Jin Medical University, Huan Hu Xi St, Tian Jin City, China 300060 (Email: wangchangli1973{at}yahoo.com).

BACKGROUND: It has been known that transcription factor nuclear factor (NF)-{kappa}B plays an important role in cell proliferation and oncogenesis. The aims of this study were to evaluate expression levels of NF-{kappa}B in nonsmall-cell lung cancer (NSCLC) and to elucidate its clinical significance and prognostic value for patients with NSCLC.

METHODS: Using 45 tumor tissue specimens from 45 patients with NSCLC who underwent surgery, we investigated the expression of NF-{kappa}B using Western blotting analysis. Apoptotic rate of NSCLC cells with different expression of NF-{kappa}B was determined by TUNEL (terminal deoxynucleotidyltransferase-mediated dUTP-biotin nick end-labeling) assay. Paraffin-embedded tissue blocks from 71 consecutive patients with NSCLC were obtained for immunohistochemical staining.

RESULTS: The expression level of NF-{kappa}B in poorly or moderately differentiated lung cancer cells was higher than that in well-differentiated ones (p = 0.001). The apoptotic rate was lower for lung cancer cells with higher NF-{kappa}B expression than for those with lower NF-{kappa}B expression (p = 0.0238). Furthermore, expression of NF-{kappa}B was correlated with caspase-3, cyclooxygenase-2, and p53 expression in lung cancer cells that were examined. Most NSCLC cells showed nuclear staining pattern and the nuclear positive rate was 67.6% (48 of 71 specimens). Immunohistochemical NF-{kappa}B expression in patients with NSCLC was an independent prognostic factor for overall survival.

CONCLUSIONS: The results of this study suggest that expression of NF-{kappa}B may correlate with lung cancer differentiation. Overexpression of NF-{kappa}B inhibits tumor cell apoptosis and indicates an unfavorable prognosis for overall survival in some patients with NSCLC.




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