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Ann Thorac Surg 2006;81:S2367-S2372
© 2006 The Society of Thoracic Surgeons

Supplement

Effects of Circuit Miniaturization in Reducing Inflammatory Response to Infant Cardiopulmonary Bypass by Elimination of Allogeneic Blood Products

Edward Hickey, MRCS a , Tara Karamlou, MD a , b , Jamie You, CCP a , Ross M. Ungerleider, MD a , *

a Division of Pediatric Cardiac Surgery, Oregon Health Sciences University, Portland Oregon
b Division of Cardiovascular Surgery, The Hospital for Sick Children, Toronto, Ontario, Canada

* Address correspondence to Dr Ungerleider, Oregon Health Sciences University, 3181 SW Sam Jackson Park Rd, Mail Code L3, Portland, OR, 97201-3098 (Email: ungerlei{at}ohsu.edu).

Presented at the Symposium on Harnessing the Effects of Neonatal Cardiopulmonary Bypass at the Fourth World Congress of Pediatric Cardiology and Cardiac Surgery, Buenos Aires, Argentina, Sept 21, 2005.

Conventional neonatal cardiopulmonary bypass requires the use of large volumes of allogeneic blood to prevent unacceptable hemodilution. Evidence is accumulating to suggest that the use of blood products during cardiopulmonary bypass has a negative effect on clinical recovery through inflammatory side effects. This would suggest an advantage for eliminating blood use in infant cardiopulmonary bypass through circuit miniaturization. In this article, we review the data supporting this rationale and provide the results from studies in our laboratory that emphasize the benefits of circuit miniaturization.




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