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Ann Thorac Surg 2006;81:S2347-S2354
© 2006 The Society of Thoracic Surgeons

Supplement

Characterizing the Inflammatory Response to Cardiopulmonary Bypass in Children

Deborah J. Kozik, DO a , b , James S. Tweddell, MD a , b , *

a The Herma Heart Center, Children's Hospital of Wisconsin, Milwaukee, Wisconsin
b Division of Cardiothoracic Surgery, Department of Surgery, Medical College of Wisconsin, Milwaukee, Wisconsin

Accepted for publication February 4, 2006.

* Address correspondence to Dr Tweddell, MS 715, Children's Hospital of Wisconsin, 9000 West Wisconsin Ave, Milwaukee, WI 53226. (Email: jtweddell{at}chw.org).

Presented at the Symposium on Harnessing the Effects of Neonatal Cardiopulmonary Bypass at the Fourth World Congress of Pediatric Cardiology and Cardiac Surgery, Buenos Aires, Argentina, Sept 21, 2005.

Cardiopulmonary bypass is known to trigger a global inflammatory response. Age-dependent differences in the inflammatory response, the increased susceptibility to injury of immature organ systems, and the larger extracorporeal circuit to patient size ratio results in greater susceptibility of younger and smaller patients to the damaging effects of cardiopulmonary bypass. In this review the components of the inflammatory response to cardiopulmonary bypass are reviewed with special reference to the pediatric age group, including the age-specific impact on organ systems. In addition the current and evolving strategies to prevent, limit, and treat the inflammatory response to cardiopulmonary bypass in children are examined.




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