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Ann Thorac Surg 2006;81:2328-2334
© 2006 The Society of Thoracic Surgeons
Division of Thoracic Surgery, Yale University, New Haven, Connecticut
Accepted for publication November 22, 2004.
* Address correspondence to Dr Detterbeck, Division of Thoracic Surgery, FMB 128, 330 Cedar St, Yale University, New Haven, CT 06520-8062 (Email: frank.detterbeck{at}yale.edu).
Since the World Health Organization (WHO) histologic classification system for thymoma was introduced in 1999, several centers have published results using this system. This review of the published experience with the WHO system examines whether the classification is reproducible, whether the WHO system defines clinically distinct patient groups, assesses the independent prognostic value of the WHO type by multivariate analysis, and discusses the impact of the WHO system on clinical management decisions.
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