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Michele Di Mauro
Gabriele Di Giammarco
Giuseppe Vitolla
Antonio Bivona
Luca Weltert
Antonio M. Calafiore
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Ann Thorac Surg 2006;81:2128-2134
© 2006 The Society of Thoracic Surgeons

Original article: Cardiovascular

Impact of No-to-Moderate Mitral Regurgitation on Late Results After Isolated Coronary Artery Bypass Grafting in Patients With Ischemic Cardiomyopathy

Michele Di Mauro, MD a , Gabriele Di Giammarco, MD a , Giuseppe Vitolla, MD a , Marco Contini, MD b , Angela L. Iacò, MD b , Antonio Bivona, MD b , Luca Weltert, MD b , Antonio M. Calafiore, MD b , *

a Division of Cardiac Surgery, University "G. D'Annunzio," Chieti
b Division of Cardiac Surgery, European Hospital, Rome, Italy

Accepted for publication January 13, 2006.

* Address correspondence to Dr Calafiore, Clinica Cardiochirurgica, European Hospital, Via Portuense 700, 00198 Rome, Italy. (Email: calafiore{at}unich.it).

BACKGROUND: This study analyzes retrospectively a cohort of patients with ischemic cardiomyopathy (ejection fraction ≤0.30) who underwent isolated coronary artery bypass grafting to evaluate the impact of no-to-moderate mitral regurgitation (MR) on long-term results.

METHODS: From January 1988 to December 2002, 6,108 patients had isolated coronary artery bypass grafting. Two hundred thirty-nine (3.9%) had ischemic cardiomyopathy; 60 patients had no, 102 had mild, and 77 had moderate MR. Using propensity score, a group of 70 patients with no or mild MR (group A) was case-matched with a group of 70 patients with moderate MR (group B) to obtain two groups with similar preoperative characteristics.

RESULTS: Nine patients (6.4%) died within the first 30 days; all deaths were cardiac-related. There was no difference in the early results between groups. Patients in group B showed lower freedom from death, from cardiac death, from cardiac death and ischemic events, and from death and New York Heart Association class III and IV than patients in group A. Cox analysis confirmed that moderate MR was an independent variable for worse late outcome in this subgroup of patients. Functional and echocardiographic results, after a mean of 62 ± 28 months in 87.8% of survivors, showed a significant impairment of New York Heart Association class (from 2.2 ± 0.5 to 2.8 ± 0.6; p < 0.001) and MR degree (from 2.0 to 2.7 ± 1.0; p = 0.023) in patients with preoperative moderate MR.

CONCLUSIONS: This study confirms that moderate ischemic MR has an important negative impact on survival and quality of life of patients with severely impaired left ventricular function, treated by coronary artery bypass grafting alone.




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