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Ann Thorac Surg 2006;81:1529-1535
© 2006 The Society of Thoracic Surgeons

Review

Physiologic Versus Anatomic Repair of Congenitally Corrected Transposition of the Great Arteries: Meta-Analysis of Individual Patient Data

Abdullah A. Alghamdi, MD * , Brian W. McCrindle, MD, Glen S. Van Arsdell, MD

Division of Cardiac Surgery and Congenital Cardiac Surgery Program, Department of Surgery, University of Toronto, Toronto, Ontario, Canada

Accepted for publication September 15, 2005.

* Address correspondence to Dr Alghamdi, Division of Cardiac Surgery and Congenital Cardiac Surgery Program, The Hospital for Sick Children, 555 University Ave, Suite 1525, Toronto, ON, Canada M5G 1X8 (Email: abdullah.alghamdi{at}utoronto.ca).

The objective of this meta-analysis of individual patients' data was to compare the immediate outcomes of anatomic and physiologic repair of congenitally corrected transposition of the great arteries. Eleven nonrandomized studies, involving 124 patients, met the inclusion criteria for this review. The Rastelli type anatomic repair and the era of surgery were significantly related to the outcome in different tested models. Entering all variables into the logistic regression model showed a significant protective effect of the Rastelli type anatomic repair (odds ratio = 0.05, 95% confidence interval: 0.01, 0.50, p = 0.02).




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