ATS
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Personal Folders
Right arrow Download to citation manager
Right arrow Author home page(s):
Ujjwal K. Chowdhury
Kizakke K. Pradeep
Balram Airan
Panangipalli Venugopal
Right arrow Permission Requests
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Chowdhury, U. K.
Right arrow Articles by Venugopal, P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Chowdhury, U. K.
Right arrow Articles by Venugopal, P.
Related Collections
Right arrow Congenital - cyanotic

Ann Thorac Surg 2006;81:1436-1442
© 2006 The Society of Thoracic Surgeons

Original article: Cardiovascular

Noninvasive Assessment of Repaired Tetralogy of Fallot by Magnetic Resonance Imaging and Dynamic Radionuclide Studies

Ujjwal K. Chowdhury, MCh, Diplomate NB * , Kizakke K. Pradeep, MS, Chetan D. Patel, DM, Rajvir Singh, MS, PhD, A. Sampath Kumar, MCh, Balram Airan, MCh, Gurpreet S. Gulati, DM, Shyam Sunder Kothari, DM, Anita Saxena, DM, Mani Kalaivani, MS, Panangipalli Venugopal, MCh

Cardiothoracic Centre, All India Institute of Medical Sciences, New Delhi, India

Accepted for publication August 29, 2005.

* Address correspondence to Dr Chowdhury, Department of CTVS, AIIMS, New Delhi-110029, India (Email: ujjwalchow{at}rediffmail.com).

BACKGROUND: This study was designed to validate the diagnostic accuracy of magnetic resonance imaging (MRI) in evaluating biventricular ejection fraction and to quantify pulmonary regurgitant fraction (PRF) in patients after repair of tetralogy of Fallot.

METHODS: Two hundred and eighty survivors of repaired tetralogy of Fallot aged 42 months to 40 years (mean, 142.2 ± 85.3 months) underwent cardiac MRI, first-pass and gated radionuclide ventriculography (RNV) for the assessment of biventricular function, and PRF after 89.26 ± 42.40 months. The receiver operating characteristic curve analysis was done to quantify the diagnostic accuracy of MRI.

RESULTS: There was statistically significant agreement between MRI and RNV in evaluating right and left ventricular function. An MRI-derived right ventricular ejection fraction 47.2% or greater than normal was associated with a sensitivity of 92.3% and a specificity of 92.3%. An MRI-derived left ventricular ejection fraction 53.9% or greater than normal was associated with a sensitivity of 93.2% and a specificity of 93.3%. Area analysis indicated that 97.34% (standard error [SE] = 0.0118) and 98.56% (SE = 0.0052) of the time values of right and left ventricular ejection fraction were higher for patients with normal right and left ventricular functions, respectively, compared with abnormal. There was a strong agreement between velocity-encoded and stroke volume-derived PRF [(r = 0.886, p < 0.001; d = 2.62 ± 1.12, p < 0.0001; r' = 0.121, p = 0.051; b = 0.96 (SE = 0.012); p< 0.0001; ICC = 0.98, p< 0.0001). Higher PRF was associated with increased indexed right ventricular dimensions and inversely correlated with biventricular ejection fractions.

CONCLUSIONS: The MRI-derived ejection fraction values predictably separate patients with normal ventricular function from abnormal. Velocity-encoded MRI can accurately quantitate PRF in tetralogy of Fallot.






HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
ANN THORAC SURG ASIAN CARDIOVASC THORAC ANN EUR J CARDIOTHORAC SURG
J THORAC CARDIOVASC SURG ICVTS ALL CTSNet JOURNALS
Copyright © 2006 by The Society of Thoracic Surgeons.