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Ann Thorac Surg 2006;81:1401-1406
© 2006 The Society of Thoracic Surgeons

Original article: Cardiovascular

Cerebral Outcome in Adult Patients Treated With Extracorporeal Membrane Oxygenation

Ivar Risnes, MD, PhD a , * , Kari Wagner, MD b , Terje Nome, MD c , Kjetil Sundet, PhD d , h , Jorun Jensen, PsyD d , Inger Annette Hynås, MD e , Thor Ueland, BS f , g , Thore Pedersen, ECCP a , Jan Ludvig Svennevig, MD, PhD a

a Department of Thoracic and Cardiovascular Surgery, Rikshospitalet University Hospital, Oslo, Norway
b Department of Anaesthesiology, Rikshospitalet University Hospital, Oslo, Norway
c Department of Radiology, Rikshospitalet University Hospital, Oslo, Norway
d Department of Psychosomatic and Behavioural Medicine, Rikshospitalet University Hospital, Oslo, Norway
e Department of Neurology, Rikshospitalet University Hospital, Oslo, Norway
f Research Institute of Internal Medicine, Rikshospitalet University Hospital, Oslo, Norway
g Institute of Immunology, Rikshospitalet University Hospital, Oslo, Norway
h Institute of Psychology, Rikshospitalet University Hospital, Oslo, Norway

Accepted for publication October 10, 2005.

* Address correspondence to Dr Risnes, Department of Thoracic and Cardiovascular Surgery, Rikshospitalet University Hospital, Oslo N-0027, Norway (Email: ivar.risnes{at}rikshospitalet.no).

BACKGROUND: Extracorporeal membrane oxygenation (ECMO) carries a high risk of brain injury. The aim of this study was to determine the cerebral status in 28 adult survivors on average 5.0 (range, 0.5 to 12) years after ECMO treatment for severe cardiorespiratory failure.

METHODS: All 28 patients were investigated at our institution. A comprehensive assessment protocol included a medical history, physical examination, neuropsychological assessment, electroencephalography, and neuroradiologic assessment.

RESULTS: All patients were ambulant unaided, and 43% were without any clinical findings. Impaired neuropsychological performance was found in 41%, neuroradiologic findings in 52%, and a pathologic electroencephalogram in 41% of the patients. There was a significant correlation between the cognitive outcome and neuroradiologic findings. The incidence of neuroradiologic findings (cerebral infarction, microemboli or hemorrhage) was significantly higher in the venoarterial group compared with the venovenous group (75% versus 17%). There was no correlation between the type of ECMO and neuropsychological impairment. Electroencephalography findings did not correlate with neuropsychological performance, nor with the neuroradiologic findings.

CONCLUSIONS: Late cerebral sequelae were frequently seen in patients treated on venoarterial ECMO. A significant correlation was found between cognitive impairment and neuroradiologic findings.


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Ann. Thorac. Surg. 2006 81: 1406-1407. [Extract] [Full Text] [PDF]



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