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Ann Thorac Surg 2006;81:1291-1296
© 2006 The Society of Thoracic Surgeons

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Original article: Cardiovascular

Hemolysis in Mechanical Bileaflet Prostheses: Experience With the Bicarbon Valve

^a Cardiovascular Service, Hospital Clinic and University of Barcelona, Barcelona, Spain
^b Cardiology Service, Hospital Clinic and University of Barcelona, Barcelona, Spain
^c Clinical Chemistry Department, Hospital Clinic and University of Barcelona, Barcelona, Spain

Accepted for publication September 21, 2005.

^_* Address correspondence to Dr Josa, Hospital Clinic and University of Barcelona, Villarroel 170, Barcelona, 08036 Spain (Email: mjosa{at}clinic.ub.es).

BACKGROUND: Normal functioning mechanical heart valve prostheses are designed to have a certain degree of intrinsic structural regurgitation as a washout mechanism to avoid prosthetic thrombosis. However, intrinsic regurgitation leads to blood cell trauma and hemolysis. Information on hemolysis associated with mechanical bileaflet prostheses is scarce. This study evaluated factors influencing hemolysis in 197 Bicarbon mechanical bileaflet prostheses implanted in 164 patients.

METHODS: Serial office interviews, laboratory studies, and echocardiography evaluations were done in the surviving patients. An assay for measuring lactate dehydrogenase activity was developed, and the presence and severity of subclinical hemolysis was determined using reported criteria and analyzed at 1 and 2 years.

RESULTS: Hospital mortality was 5.5%. Follow-up was 98.1% complete. No patient had clinically significant or severe subclinical hemolysis. Serum lactate dehydrogenase levels were significantly higher when a paravalvular leak was documented (282 ± 85 U/L versus 242 ± 64 U/L; p = 0.0026). Subclinical hemolysis was significantly more frequent after mitral valve (p = 0.001) and double valve replacement (p = 0.001) than after aortic valve replacement, and was unrelated to prosthetic size or to geometric area index, even in those cases with effective orifice area index equal to or less than 0.85 cm²/m² (p = 0.298).

CONCLUSIONS: Mild subclinical hemolysis is frequently associated with normal functioning Bicarbon heart valves. Subclinical hemolysis was significantly influenced by valve position but not by valve size or effective orifice area index and remained stable through time. The magnitude of hemolysis in Bicarbon prostheses compared favorably with that reported for other bileaflet heart valve prostheses.

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