HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Personal Folders Download to citation manager Author home page(s): Paolo Biglioli Alessandro Parolari Permission Requests Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Cavalca, V. Articles by Parolari, A. Search for Related Content PubMed PubMed Citation Articles by Cavalca, V. Articles by Parolari, A. Related Collections Extracorporeal circulation

Ann Thorac Surg 2006;81:562-567
© 2006 The Society of Thoracic Surgeons

---

Original article: Cardiovascular

Isoprostanes and Oxidative Stress in Off-Pump and On-Pump Coronary Bypass Surgery

^a Centro Cardiologico Monzino IRCCS, University of Milan, Milan, Italy
^b Institute of Cardiology, University of Milan, Milan, Italy
^c Department of Pharmacological Sciences, University of Milan, Milan, Italy
^d Department of Medical Chemistry, Biochemistry, and Biotechnology, University of Milan, Milan, Italy
^e Center for Cardiopulmonary Pharmacology, University of Milan, Milan, Italy

Accepted for publication August 18, 2005.

^_* Address correspondence to Dr Parolari, Centro Cardiologico Monzino IRCCS, Via Carlo Parea 4, 20138 Milan, Italy (Email: aparolari{at}ccfm.it).

BACKGROUND: Conventional on-pump coronary artery bypass grafting (CABG) is associated with a systemic inflammatory response and by an increased production of reactive oxygen species, whereas off-pump coronary artery bypass grafting (OPCAB) is thought to be accompanied by less oxidative stress. Urinary isoprostane iPF₂-III is a new marker reflecting oxidative stress; it has emerged as the most reliable marker of oxidative stress status in vivo. This study was designed to ascertain whether OPCAB compared with CABG represents a surgical strategy that avoids oxidative stress. To this end urinary isoprostanes and other established oxidative stress markers were measured during the first 24 hours after CABG and OPCAB.

METHODS: Fifty low-risk coronary patients were randomly assigned to CABG or OPCAB. Urinary isoprostane iPF₂-III levels, plasma levels of free malondialdehyde, and total antioxidant status were measured before, during, and up to 24 hours after surgery.

RESULTS: In OPCAB iPF₂-III excretion remained unchanged throughout the study. As expected, in CABG iPF₂-III levels significantly increased during surgery and returned at baseline 24 hours later. Free malondialdehyde behaved similarly, with no change in OPCAB and sharp increases during CABG. Conversely, total antioxidant status showed a sharp drop during CABG, followed by a slow recovery, whereas a significantly lower drop occurred in OPCAB.

CONCLUSIONS: In this randomized study in low-risk coronary patients, OPCAB revealed less perioperative oxidative stress, as reflected by lack of excretion of iPF₂-III in urine, by lack of increase of plasma free malondialdehyde, and by lower decreases in plasma total antioxidant status.

This article has been cited by other articles:

				I. Mueed, T. Tazzeo, C. Liu, E. Pertens, Y. Zhang, I. Cybulski, L. Semelhago, J. Noora, A. Lamy, K. Teoh, et al. Isoprostanes constrict human radial artery by stimulation of thromboxane receptors, Ca2+ release, and RhoA activation J. Thorac. Cardiovasc. Surg., January 1, 2008; 135(1): 131 - 138. [Abstract] [Full Text] [PDF]