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Ann Thorac Surg 2006;81:366-368
© 2006 The Society of Thoracic Surgeons

Case report

ACTH Secreting Thymic Carcinoid Associated With Multiple Endocrine Neoplasia Type 1

Motoki Yano, MD, PhD * , Ichiro Fukai, MD, PhD, Yoshihiro Kobayashi, MD, PhD, Kotaro Mizuno, MD, PhD, Akimitsu Konishi, MD, PhD, Hiroshi Haneda, MD, Eriko Suzuki, MD, Katsuhiko Endo, MD, Yoshitaka Fujii, MD, PhD

Department of Surgery II, Nagoya City University Medical School, Nagoya, Aichi, Japan

Accepted for publication July 29, 2004.

* Address correspondence to Dr Yano, Nagoya City University Medical School, Department of Surgery II, 1 Kawasumi, Mizuho, Nagoya, Aichi 467–8601, Japan (Email: motoki{at}med.nagoya-cu.ac.jp).

Thymic carcinoids are classified into three categories: (1) nonsecretory tumors, (2) hormonal secretory tumors, and (3) tumors associated with multiple endocrine neoplasia type 1. We report a rare case with adrenocorticotropic hormone secreting thymic carcinoid with multiple endocrine neoplasia type 1. Radiologic examination showed an anterior mediastinal mass and a parathyroid tumor. Blood analysis revealed high levels of parathyroid hormone and adrenocorticotropic hormone. Urine cortisol and 17-hydroxycorticoids levels were also elevated. Extended thymectomy was performed. Subsequently adjuvant radiation therapy and parathyroid tumor resection were performed. A germline mutation of exon 7 in the multiple endocrine neoplasia type 1 gene was detected and a somatic mutation of exon 9 was demonstrated in the thymic tumor.






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