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Ann Thorac Surg 2006;81:298-304
© 2006 The Society of Thoracic Surgeons

Original article: General thoracic

Pleural Lavage Cytology Before and After Lung Resection in Non-Small Cell Lung Cancer Patients

Sotarou Enatsu, MD a , c , * , Junji Yoshida, MD a , Tomoyuki Yokose, MD b , Mitsuyo Nishimura, MD a , Yutaka Nishiwaki, MD a , Takayuki Shirakusa, MD c , Kanji Nagai, MD a

a Department of Thoracic Oncology, National Cancer Center Hospital East, Kashiwa, Japan
b Department of Pathology, National Cancer Center Research Institute East, Kashiwa, Japan
c Second Department of Surgery, Fukuoka University School of Medicine, Fukuoka City, Japan

Accepted for publication June 27, 2005.

* Address correspondence to Dr Enatsu, Second Department of Surgery, Fukuoka University School of Medicine, 7-45-1, Nanakuma, Jonan-ku, Fukuoka City, Fukuoka, 814-0180, Japan (Email: md040004{at}cis.fukuoka-u.ac.jp).

BACKGROUND: The aim of this study was to analyze on a multivariate basis the prognostic significance of pre-resection and post-resection pleural lavage cytologies in surgically resected primary non-small cell lung cancer (NSCLC) patients, in relation to pathologic TNM factors in a large cohort of almost 1,200 patients.

METHODS: From August 1992 through March 2001, pleural lavage cytology (PLC) was performed in 1,214 NSCLC patients without pleural effusion or dissemination undergoing pulmonary resection. The cytologic evaluation was classified into three categories: negative, suggestive, and positive. To investigate the impact on patient survival, PLC results were analyzed with conventional clinicopathologic factors.

RESULTS: Definitive pre-resection PLC result was obtained in 1,194 patients and 38 had a positive result. The 5-year survival rates were 27% if pre-resection PLC was positive and 71% if negative. Of 1,198 patients 54 had a positive post-resection PLC result. The 5-year survival rates were 10% if post-resection PLC was positive and 73% if negative. On multivariate analysis, post-resection PLC was an independent prognostic factor as significant as established clinicopathologic factors.

CONCLUSIONS: Pre-resection and post-resection PLC should be recognized as an essential prognostic factor and should be performed in NSCLC patients without pleural effusion and dissemination. Post-PLC, compared with pre-PLC, had a greater and independent impact on survival and needs to be incorporated in the pathologic staging of NSCLC in the future.




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