HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Personal Folders Download to citation manager Author home page(s): Susan D. Moffatt-Bruce John Karamichalis Robert C. Robbins Richard I. Whyte Bruce A. Reitz Permission Requests Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Moffatt-Bruce, S. D. Articles by Reitz, B. A. Search for Related Content PubMed PubMed Citation Articles by Moffatt-Bruce, S. D. Articles by Reitz, B. A. Related Collections Lung - transplantation

Ann Thorac Surg 2006;81:286-291
© 2006 The Society of Thoracic Surgeons

---

Original article: General thoracic

Are Heart-Lung Transplant Recipients Protected From Developing Bronchiolitis Obliterans Syndrome?

^a Department of Cardiothoracic Surgery, Stanford University, Stanford, California
^b Division of Pulmonary and Critical Care Medicine, Stanford University, Stanford, California

Accepted for publication August 15, 2005.

^_* Address correspondence to Dr Reitz, Department of Cardiothoracic Surgery, Stanford School of Medicine, CVRB Falk Research Building, 300 Pasteur Dr, Stanford, CA 94305–5407 (Email: breitz{at}stanford.edu).

Presented at the Fortieth Annual Meeting of The Society of Thoracic Surgeons, San Antonio, TX, Jan 26–28, 2004.

BACKGROUND: Heart-lung transplant recipients, when compared with heart transplant recipients, are relatively spared from allograft coronary artery disease. This study was undertaken to investigate whether heart-lung transplant recipients are also spared from experiencing bronchiolitis obliterans syndrome (BOS) when compared with double-lung transplant recipients. In addition, the risk factors for developing BOS after lung transplantation were analyzed.

METHODS: Heart-lung and bilateral sequential double-lung transplant recipients were reviewed retrospectively from 1990 to 2000 using the Stanford Transplant Database. The heart-lung transplant group consisted of 77 heart-lung transplant recipients and the double-lung transplant group consisted of 51 double-lung transplant recipients. The rates of BOS, survival, acute rejection, and cytomegalovirus infection at 1, 3, and 5 years were measured.

RESULTS: There were no significant differences in patient demographics between the two groups. Rates of survival and acute rejection were similar in the two transplant groups. The incidence of cytomegalovirus infection was significantly higher in heart-lung transplant recipients. Freedom from BOS was similar in the two transplant groups. Risk factors for the development of BOS in the heart-lung and double-lung transplant recipients included male donor, younger recipient age, a diagnosis other than cystic fibrosis, nonuse of cardiopulmonary bypass, and the use of OKT3 induction therapy.

CONCLUSIONS: Heart-lung transplant recipients exhibit BOS at a rate similar to double-lung transplant recipients. The immunoprotective effect the lung allograft presumably provides the heart is not reciprocated by the heart in preventing the development of BOS.

This article has been cited by other articles:

				E. Fadel, O. Mercier, S. Mussot, F. Leroy-Ladurie, J. Cerrina, A. Chapelier, G. Simonneau, and P. Dartevelle Long-term outcome of double-lung and heart-lung transplantation for pulmonary hypertension: a comparative retrospective study of 219 patients Eur J Cardiothorac Surg, September 1, 2010; 38(3): 277 - 284. [Abstract] [Full Text] [PDF]

				T. Deuse, R. Sista, D. Weill, D. Tyan, F. Haddad, G. Dhillon, R. C. Robbins, and B. A. Reitz Review of Heart-Lung Transplantation at Stanford Ann. Thorac. Surg., July 1, 2010; 90(1): 329 - 337. [Abstract] [Full Text] [PDF]

				T. Martinu, D.-F. Chen, and S. M. Palmer Acute Rejection and Humoral Sensitization in Lung Transplant Recipients , January 15, 2009; 6(1): 54 - 65. [Abstract] [Full Text] [PDF]