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Kosmas Iliadis
Theodosios Dosios
Ion Bellenis
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Ann Thorac Surg 2005;80:1056-1062
© 2005 The Society of Thoracic Surgeons

Original article: General thoracic

Prognostic Factors in Thymic Epithelial Tumors Undergoing Complete Resection

Charalambos Zisis, MD a , * , Dimitra Rontogianni, MD b , Chara Tzavara, MD b , Kalliopi Stefanaki, MD c , Antonios Chatzimichalis, MD a , Antonios Loutsidis, MD a , * , Kosmas Iliadis, MD d , Argirios Kontaxis, MD d , Theodosios Dosios, MD, PhD e , Ion Bellenis, MD a

a Department of Thoracic Surgery and Pathology, "Evangelismos" Hospital, Athens, Greece
b Department of Biostatistics, University of Athens, Athens, Greece
c Department of Pathology, "Aghia Sofia" Pediatric Hospital, Athens, Greece
d Department of Thoracic Surgery, "Hygia" Hospital, Athens, Greece
e Division of Thoracic Surgery, Athens University School of Medicine, Athens, Greece

Accepted for publication March 23, 2005.

* Address reprint requests to Dr Zisis, 17A, Patriarchou Grigoriou str, 166 74-Glyfada, Athens, Greece (Email: chzisis{at}otenet.gr).

BACKGROUND: The prognostic factors in thymic epithelial tumors (TET) are investigated within a 27-year period in 104 patients submitted to surgical and pathologic complete resection of TET with a mean age of 53 ± 14.6 years and a male to female ratio of 0.73.

METHODS: The medical records of all patients were reviewed and six variables that could affect the short-term and long-term survival were entered into a Cox regression model. Follow-up was obtained from medical records and telephone contacts up to September 2004 or until the patient’s death.

RESULTS: Overall 5-year and 10-year survival was 83% and 78%, respectively. Univariate Cox regression analysis showed that long survival was affected by the age of the patient at the time of operation, the response of myasthenia gravis to the operation, the tumor recurrence, the histologic type according to the World Health Organization (WHO) classification, and the Masaoka stage. Multivariate analysis revealed that recurrence of the tumor (p = 0.001), Masaoka stages II or III (p < 0.001), elder age of the patient at the time of operation (p = 0.045), and presence of the WHO histologic types B2 or B3 (p = 0.05) were bad prognostic factors.

CONCLUSIONS: Recurrence of the tumor, the Masaoka staging, the WHO histologic type, and the age of the patient at the time of operation were the most important prognosticators for patients with TET submitted to complete resection of their tumor.






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