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Ann Thorac Surg 2005;80:712-714
© 2005 The Society of Thoracic Surgeons

Case report

Cell Therapy Plus Transmyocardial Laser Revascularization for Refractory Angina

Luís Henrique W. Gowdak, MD, PhD * , Isolmar T. Schettert, MD, Carlos Eduardo Rochitte, MD, PhD, Luiz Augusto F. Lisboa, MD, PhD, Luís Alberto O. Dallan, MD, PhD, Luiz Antônio M. César, MD, PhD, José Eduardo Krieger, MD, PhD, José Antônio F. Ramires, MD, PhD, Sérgio A. de Oliveira, MD, PhD

Heart Institute (InCor), University of São Paulo Medical School, São Paulo, Brazil

Accepted for publication April 25, 2005.

* Address reprint requests to Dr Gowdak, Heart Institute (InCor), University of São Paulo Medical School, Av Dr Enéas de Carvalho Aguiar, 44, São Paulo, SP, 05403-000 Brazil (Email: luis.gowdak{at}incor.usp.br).

We describe the use of autologous bone marrow cells combined with transmyocardial laser revascularization in a 74-year-old man with refractory angina. Baseline cardiac magnetic resonance imaging revealed a markedly depressed left ventricle systolic function and an extensive area of myocardial ischemia. During surgery, 11 laser shots using a CO2 Heart Laser System (PLC Medical Systems, Milford, MA) were fired and a 5-mL cell suspension containing 21.5 x 106 bone marrow cells/mL was delivered by multiple injections into the myocardium. At 6 months after the procedure, another cardiac magnetic resonance imaging showed an almost complete resolution of the perfusion defect and an improvement in left ventricular contractility.




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 Eur. J. Cardiothorac. Surg.Home page
S. A. de Oliveira, L. H. W. Gowdak, G. Buckberg, J. E. Krieger, and the RESTORE Group
Cell biology, MRI and geometry: insight into a microscopic/macroscopic marriage
Eur. J. Cardiothorac. Surg., April 1, 2006; 29(Suppl_1): S259 - S265.
[Abstract] [Full Text] [PDF]


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