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Arvind K. Agnihotri
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Right arrow Valve disease

Ann Thorac Surg 2005;80:704-707
© 2005 The Society of Thoracic Surgeons

New technology

A Stentless Trileaflet Valve From a Sheet of Decellularized Porcine Small Intestinal Submucosa

Jennifer K. White, MD * , Arvind K. Agnihotri, MD, James S. Titus, David F. Torchiana, MD

Division of Cardiac Surgery, Massachusetts General Hospital, Boston, Massachusetts

Accepted for publication August 26, 2004.

* Address reprint requests to Dr White, Division of Cardiac Surgery, Massachusetts General Hospital, Bullfinch 119/50 Fruit St, Boston, MA 02114 (Email: jkwhite{at}partners.org).

PURPOSE: The purpose of this study was to investigate the function of a trileaflet pulmonary valve constructed from a sheet of porcine small intestinal submucosa.

DESCRIPTION: In four sheep, the native pulmonary valve and a segment of the pulmonary trunk was excised and replaced with a trileaflet valve constructed from decellularized porcine small intestinal submucosa. The valve construct was created from a sheet of the xenograft material by a method of involuting flaps of tissue inside a cylinder of itself. The function of the valve was assessed by echocardiography, catheter pullback across the valve, and observation of an excised valve in a flow simulator.

EVALUATION: The valve constructs exhibited low gradients and symmetrical leaflet movement with good mobility when tested under physiologic conditions in an acute sheep model.

CONCLUSIONS: This method offers a means to create a functional trileaflet valve replacement from a sheet of tissue.




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