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Hiroshi Takano
Yuji Miyamoto
Yoshiki Sawa
Norihide Fukushima
Goro Matsumiya
Tomoyuki Fujita
Hikaru Matsuda
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Ann Thorac Surg 2005;80:320-322
© 2005 The Society of Thoracic Surgeons

Case report

Successful Mitral Valve Replacement in a Patient With Ehlers-Danlos Syndrome Type VI

Hiroshi Takano, MD*, Yuji Miyamoto, MD, Yoshiki Sawa, MD, Norihide Fukushima, MD, Goro Matsumiya, MD, Tomoyuki Fujita, MD, Hikaru Matsuda, MD

Division of Cardiovascular Surgery, Department of Surgery, Osaka University Graduate School of Medicine, Suita, Osaka, Japan

Accepted for publication December 22, 2003.

* Address reprint requests to Dr Takano, Department of Surgery E-1, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan (Email: htakano-cvs{at}umin.ac.jp).

A 40-year-old patient with Ehlers-Danlos syndrome type VI (ocular type) had mitral regurgitation due to mitral valve prolapse. Because the patient’s tissue was fragile, we replaced the mitral valve with a reinforced prosthetic valve to prevent paravalvular leakage. The excised mitral leaflet showed significant myxomatous change and decrease in collagen fibers. We believe this is the first report of cardiac surgery in a patient with Ehlers-Danlos syndrome type VI.






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