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Ann Thorac Surg 2005;80:299-303
© 2005 The Society of Thoracic Surgeons

New technology

Preemptive Use of Bivalirudin for Urgent On-Pump Coronary Artery Bypass Grafting in Patients With Potential Heparin-Induced Thrombocytopenia

Cornelius M. Dyke, MDa,*, Andreas Koster, MDb, James J. Veale, CCPa, George W. Maier, MDa, Thomas McNiff, MDa, Jerrold H. Levy, MDc

a Department of Surgery and Anesthesiology, Gaston Memorial Hospital, Gastonia, North Carolina
b Department of Anesthesia, Deutsches Herzzentrum, Berlin, Germany
c Department of Cardiothoracic Anesthesiology, Emory University School of Medicine, Atlanta, Georgia

Accepted for publication August 19, 2004.

* Address reprint requests to Dr Dyke, Sanger Clinic-Gastonia, Suite 200, 2555 Court Dr, Gastonia, NC 28054 (Email: cdyke{at}sanger-clinic.com).

PURPOSE: The use of heparin in patients with heparin-induced thrombocytopenia (HIT) may result in severe complications or death. The diagnosis of HIT is frequently uncertain, however. Alternative anticoagulants in at-risk patients undergoing cardiac surgery with cardiopulmonary bypass remain problematic. The novel short-acting, direct-thrombin inhibitor bivalirudin is the only alternative to heparin/protamine being used in elective non-HIT patients during CPB.

DESCRIPTION: Four patients with severe thrombocytopenia after heparin exposure and suspected acute HIT underwent on-pump coronary artery bypass grafting surgery with preemptive use of bivalirudin. A continuous bivalirudin infusion was used during cardiopulmonary bypass, and activated clotting times were used to monitor anticoagulation.

EVALUATION: Anticoagulation with bivalirudin during cardiopulmonary bypass was effective and uncomplicated. Duration of operation was not prolonged, and perioperative blood loss and transfusion rates were acceptable. Activated clotting times were helpful for monitoring anticoagulation in these patients.

CONCLUSIONS: These data provide further evidence of the feasibility of bivalirudin for anticoagulation during on-pump coronary artery bypass graft surgery in urgent clinical situations.


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Simon C. Moten and Brian Buxton
Ann. Thorac. Surg. 2005 80: 303. [Extract] [Full Text] [PDF]



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