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Richard D. Weisel
Terrence M. Yau
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Ann Thorac Surg 2005;79:S2238-S2247
© 2005 The Society of Thoracic Surgeons

Supplement

Current Status of Cellular Therapy for Ischemic Heart Disease

Shafie Fazel, MD, MS, Gilbert H.L. Tang, MD, Denis Angoulvant, MD, MS, Massimo Cimini, PhD, Richard D. Weisel, MD, Ren-Ke Li, MD, PhD, Terrence M. Yau, MD, MS*

Division of Cardiovascular Surgery, Toronto General Hospital, University Health Network, Department of Surgery, University of Toronto, Heart and Stroke Foundation/Richard Lewar Centre of Excellence, Toronto, Ontario, Canada

Accepted for publication February 21, 2005.

* Address reprint requests to Dr Yau, Division of Cardiovascular Surgery, Toronto General Hospital, University Health Network, 13EN-239, 200 Elizabeth St, Toronto, Ontario, Canada, M5G 2C4 (E-mail: terry.yau{at}utoronto.ca).

Presented at the 4th Annual Lillehei Heart Institute Symposium Celebrating the 50th Anniversary of Open-Heart Surgery by Cross Circulation, Minneapolis, MN, Oct 19–20, 2004.

Cellular therapy for acute myocardial infarction and ischemic cardiomyopathy has entered clinical trials across the globe. Early promising results have now provided the justification for larger randomized and blinded trials to address the efficacy of cellular therapy. A variety of fresh or cultured autologous cells have been delivered by catheter-guided endocardial, catheter-guided intracoronary, catheter-guided transvenous, and direct epicardial routes. This review will summarize the clinical data and highlight salient basic science data that support the ongoing efforts to identify the optimal cellular therapy both for acute myocardial infarction and chronic ischemic cardiomyopathy patients.




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