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Marc de Perrot
Syed M. Quadri
Shaf Keshavjee
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Right arrow Lung - transplantation

Ann Thorac Surg 2005;79:2169-2171
© 2005 The Society of Thoracic Surgeons

How to do it

Independent Ventilation of the Graft and Native Lungs In Vivo After Rat Lung Transplantation

Marc de Perrot, MD, Syed M. Quadri, MD, Yumiko Imai, MD, Shaf Keshavjee, MD*

Thoracic Surgery Research Laboratory, Toronto General Hospital Research Institute, University of Toronto, Toronto, Ontario, Canada

Accepted for publication January 28, 2004.

* Address reprint requests to Dr Keshavjee, Thoracic Surgery Research Laboratory, Toronto General Hospital, 200 Elizabeth St, EN 10-224, Toronto, Ontario M5G 2C4, Canada (E-mail: shaf.keshavjee{at}uhn.on.ca).

Rat lung transplantation is a proven experimental technique for the study of lung injury following lung transplantation. We have modified the surgical and ventilatory techniques to allow for independent ventilation in vivo of the transplanted graft and native lungs. This will provide additional data on the physiology and function of the transplanted graft and ameliorate the problem of progressive graft lung collapse and thereby allow for an improved model of ischemia-reperfusion injury and ventilator-induced lung injury in the setting of lung transplantation.




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 Ann. Thorac. Surg.Home page
H. Inokawa, M. Sevala, W. K. Funkhouser, and T. M. Egan
Ex-vivo perfusion and ventilation of rat lungs from non-heart-beating donors before transplant.
Ann. Thorac. Surg., October 1, 2006; 82(4): 1219 - 1225.
[Abstract] [Full Text] [PDF]


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