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Ann Thorac Surg 2005;79:1797-1804
© 2005 The Society of Thoracic Surgeons

Review

Development of the Atrioventricular Valves: Clinicomorphological Correlations

Mazyar Kanani, MRCSa,*, Antoon F.M. Moorman, PhDb, Andrew C. Cook, PhDa, Sandra Webb, PhDc, Nigel A. Brown, PhDc, Wouter H. Lamers, MD, PhDb, Robert H. Anderson, MD, FRCPatha

a Institute of Child Health, London, United Kingdom
b Department of Anatomy and Embryology, Academic Medical Centre, Amsterdam, the Netherlands
c Department of Basic Medical Sciences, Anatomy and Developmental Biology, St. George's Hospital Medical School, London, United Kingdom

Accepted for publication June 25, 2004.

* Address reprint requests to Dr Kanani, Cardiac Unit, Institute of Child Health, 30 Guilford St, London WC1H 1EJ, UK; (E-mail: m.kanani{at}ich.ucl.ac.uk).

The atrioventricular valves are formed from a complex arrangement of an annulus and leaflets, supported by a subvalvar apparatus that is composed of tendinous cords and papillary muscles. Although much has been said and written about their development, the exact nature of the process has yet to be fully elucidated. We believe that this is vital, since unraveling this complex process holds the key to the understanding of many of the congenital malformations that may afflict the valves.




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