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Ann Thorac Surg 2005;79:1755-1758
© 2005 The Society of Thoracic Surgeons

Case report

Histopathologic Findings in a Novel Decellularized Pulmonary Homograft: An Autopsy Study

Friedhelm Sayk, MDa,*, Inge Bos, MDa, Ute Schubert, BSb, Thilo Wedel, MDc, Hans-H. Sievers, MDb

a Institute of Pathology, University of Luebeck, Luebeck, Germany
b Clinic for Cardiovascular Surgery, University of Luebeck, Luebeck, Germany
c Institute of Anatomy, University of Luebeck, Luebeck, Germany

Accepted for publication November 7, 2003.

* Address reprint requests to Dr Sayk, Institute of Pathology, University of Luebeck, Ratzeburger Allee 160, 23538 Luebeck, Germany
friedhelm.sayk{at}innere1.uni-luebeck.de

Innovative valved conduits for reconstruction of the right ventricular outflow tract are desirable to overcome the risk of valve deterioration of conventional homografts. This study describes the histopathology of a novel decellularized pulmonary homograft (SynerGraft) implanted in the right ventricular outflow tract of a 60-year-old man 5 weeks before death. The histomorphology of this decellularized homograft showed integrity of its extracellular matrix and a gradual cellular infiltrate consisting predominantly of macrophages, resembling an early nonspecific inflammatory phase of recellularization without any signs of a specific immunologic interference 5 weeks after implantation. Whether this morphologic appearance precedes the desired repopulation with autologous fibroblasts remains to be established.




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