HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Personal Folders Download to citation manager Author home page(s): Marc de Perrot Elie Fadel Sacha Mussot Alain Chapelier Philippe Dartevelle Permission Requests Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by de Perrot, M. Articles by Dartevelle, P. Search for Related Content PubMed PubMed Citation Articles by de Perrot, M. Articles by Dartevelle, P. Related Collections Lung - cancer

Ann Thorac Surg 2005;79:1691-1696
© 2005 The Society of Thoracic Surgeons

---

Original articles: General thoracic

Resection of Locally Advanced (T4) Non-Small Cell Lung Cancer With Cardiopulmonary Bypass

Department of Thoracic and Vascular Surgery and Heart-Lung Transplantation, Hôpital Marie-Lannelongue, Le Plessis-Robinson, France

Accepted for publication October 14, 2004.

^_* Address reprint requests to Dr Dartevelle, Department of Thoracic and Vascular Surgery and Heart-Lung Transplantation, Hôpital Marie-Lannelongue, 133 Avenue de la Résistance, 92350 Le Plessis-Robinson, France (E-mail: pdartevelle{at}ccml.com).

BACKGROUND: Resection of T4 non-small cell lung cancer (NSCLC) on cardiopulmonary bypass (CPB) has rarely been reported in the literature. Hence, we have reviewed our experience in the role of CPB for the surgical treatment of locally advanced NSCLC.

METHODS: All patients undergoing lung resection for bronchogenic carcinoma on CPB in our institution between January 1998 and June 2004 were reviewed.

RESULTS: Seven patients underwent lung resections on CPB for bronchogenic carcinoma during the study period. Cardiopulmonary bypass was performed for tumors invading the subclavian artery down to the aortic arch (n = 2), the descending aorta (n = 1), or the origin of the left pulmonary artery with the left atrium (n = 2). All patients were discharged home after 9 to 21 days (median, 15 days). In the long term, 2 patients are alive without recurrence 17 and 25 months after their operations, and 3 are alive with recurrence 8, 13, and 54 months postoperatively. Two additional patients required CPB while undergoing carinal resection for difficulty ventilating the left lung. Both patients had a difficult postoperative course, but were eventually discharged from hospital. One patient died without recurrence 6 months later, and the other is alive without recurrence after 72 months.

CONCLUSIONS: This study confirms the safety of CPB for NSCLC invading the great vessels and/or the left atrium in well-selected patients, and its utility when pulmonary edema develops during carinal resection. Further studies, however, are required to confirm long-term survival.

This article has been cited by other articles:

				A. Muralidaran, F. C. Detterbeck, D. J. Boffa, Z. Wang, and A. W. Kim Long-term survival after lung resection for non-small cell lung cancer with circulatory bypass: A systematic review J. Thorac. Cardiovasc. Surg., November 1, 2011; 142(5): 1137 - 1142. [Abstract] [Full Text] [PDF]

				G. Lang, S. Taghavi, C. Aigner, R. Charchian, J. R. Matilla, A. Sano, and W. Klepetko Extracorporeal Membrane Oxygenation Support for Resection of Locally Advanced Thoracic Tumors Ann. Thorac. Surg., July 1, 2011; 92(1): 264 - 270. [Abstract] [Full Text] [PDF]

				P. Berna, P. Bagan, F. De Dominicis, C. Dayen, Y. Douadi, and M. Riquet Aortic Endostent Followed by Extended Pneumonectomy for T4 Lung Cancer Ann. Thorac. Surg., February 1, 2011; 91(2): 591 - 593. [Abstract] [Full Text] [PDF]

				A. Chambers, T. Routledge, A. Bille, and M. Scarci Does surgery have a role in T4N0 and T4N1 lung cancer? Interact CardioVasc Thorac Surg, October 1, 2010; 11(4): 473 - 479. [Abstract] [Full Text] [PDF]

				A. Gomez-Caro, E. Martinez, A. Rodriguez, D. Sanchez, J. Martorell, J. M. Gimferrer, A. Haverich, W. Harringer, J. L. Pomar, and P. Macchiarini Cryopreserved Arterial Allograft Reconstruction After Excision of Thoracic Malignancies Ann. Thorac. Surg., December 1, 2008; 86(6): 1753 - 1761. [Abstract] [Full Text] [PDF]

				B. Yildizeli, P. G. Dartevelle, E. Fadel, S. Mussot, and A. Chapelier Results of Primary Surgery With T4 Non-Small Cell Lung Cancer During a 25-Year Period in a Single Center: The Benefit is Worth the Risk Ann. Thorac. Surg., October 1, 2008; 86(4): 1065 - 1075. [Abstract] [Full Text] [PDF]

				W. Weder Editorial comment: Extended pulmonary resections of advanced thoracic malignancies with support of cardio-pulmonary bypass -- is surgery justified? Eur J Cardiothorac Surg, April 1, 2006; 29(4): 577 - 578. [Full Text] [PDF]

				M. de Perrot, E. Fadel, O. Mercier, S. Mussot, A. Chapelier, and P. Dartevelle Long-term results after carinal resection for carcinoma: Does the benefit warrant the risk? J. Thorac. Cardiovasc. Surg., January 1, 2006; 131(1): 81 - 89. [Abstract] [Full Text] [PDF]