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Ann Thorac Surg 2005;79:1378-1383
© 2005 The Society of Thoracic Surgeons

New technology

MagScrew Total Artificial Heart In Vivo Performance Above 200 Beats Per Minute

Soren Schenk, MDa, Stephan Weber, Dipl Inga, Viviane Luangphakdy, MSBMEa, Ryan S. Klatte, BSBMEa, Christine R. Flick, BSBMEa, Ji-Feng Chen, BSa, Michael W. Kopcak, Jr, BAa, Yoshio Ootaki, MD, PhDa, Keiji Kamohara, MDa, Gordon B. Hirschman, MEng EEb, Nicholas G. Vitale, BSMEb, Peter A. Chapman, Jr, BSME PEb, William A. Smith, D Eng PEa, Kiyotaka Fukamachi, MD, PhDa,*

a Department of Biomedical Engineering, The Cleveland Clinic Foundation, Cleveland, Ohio,, USA
b Foster-Miller Technologies, Albany, New York, USA

Accepted for publication March 15, 2004.

* Address reprint requests to Dr Fukamachi, Department of Biomedical Engineering, ND20, The Cleveland Clinic Foundation, 9500 Euclid Ave, Cleveland, OH 44195, USA
fukamach{at}bme.ri.ccf.org

PURPOSE: Downsizing pulsatile devices requires an increase of beat rate if flow capacity is to be maintained. We applied this concept to the preclinical MagScrew total artificial heart (TAH).

DESCRIPTION: The device fills passively with a stroke volume of 45 ml and beat rates up to 250 beats per minute (bpm).

EVALUATION: Stable hemodynamics were observed during a 30-day bovine implant with a flow of 8.7 ± 1.2 L/min at beat rates of 204 ± 18 bpm. Device filling was exceptional up to 250 bpm generating flow of greater than 12 L/min. Beat rate adapted to preload in a way similar to a Frank-Starling response. Left and right atrial pressures were balanced. The aortic pulse pressure was 49–70 mm Hg, which translates to a pulsatility index of 0.49–0.77. Organ functions were preserved and blood damage did not occur.

CONCLUSIONS: Increasing the beat rate while downsizing the MagScrew TAH was successful with strong flow generation by passive filling. Pulsatility was maintained at high beat rates. This innovative approach may be used to develop small pulsatile pumps.




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 Ann. Thorac. Surg.Home page
S. Schenk, S. Weber, W. A. Smith, and K. Fukamachi
MagScrew Total Artificial Heart
Ann. Thorac. Surg., June 1, 2006; 81(6): 2338 - 2339.
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