ATS
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Personal Folders
Right arrow Download to citation manager
Right arrow Permission Requests
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Lawson, J. H.
Right arrow Articles by Parker, W.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Lawson, J. H.
Right arrow Articles by Parker, W.
Related Collections
Right arrow Cardiac - pharmacology

Ann Thorac Surg 2005;79:1037-1038
© 2005 The Society of Thoracic Surgeons

Case report

Antihuman Factor V Antibodies After Use of Relatively Pure Bovine Thrombin

Jeffrey H. Lawson, MD, PhDa,b,*, Kellie A. Lynn, RNa, Reed M. Vanmatre, MDd, Taymon Domzalski, BAa, Keith F. Klemp, BSc, Thomas L. Ortel, MD, PhDb,c, Laura E. Niklason, MD, PhDa,d, William Parker, PhDa

a Department of Surgery, Duke University Medical Center, Durham, North Carolina, USA
b Department of Pathology, Duke University Medical Center, Durham, North Carolina, USA
c Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA
d Department of Anesthesiology, Duke University Medical Center, Durham, North Carolina, USA

Accepted for publication September 22, 2003.

* Address reprint requests to Dr Lawson, Department of Surgery, Box 2622, Duke University Medical Center, Durham, NC 27710, USA
lawso717{at}acpub.duke.edu

Although bovine thrombin is commonly used in the operating room, there is evidence that exposure to bovine thrombin can result in the development of autoimmune antibodies, usually against factor V, which can lead to a profound coagulopathy. It is thought that impurities in bovine thrombin preparations are responsible for the adverse reactions in patients. Here we describe a case in which exposure to a relatively pure bovine thrombin preparation resulted in the development of an antihuman factor V antibody-associated coagulopathy. This report calls into question the safety of even relatively pure bovine thrombin.




This article has been cited by other articles:


Home page
 CLIN APPL THROMB HEMOSTHome page
J. M. Walenga, R. L. Bick, and H. L. Messmore
Antigenic (Immunogenic) Profiling of Bovine Thrombin and its Purified Forms
Clinical and Applied Thrombosis/Hemostasis, April 1, 2008; 14(2): 133 - 134.
[PDF]

Home page
 CLIN APPL THROMB HEMOSTHome page
A. Terrab, D. Pawlak, P. Spaay, D. Hoppensteadt, and J. Fareed
Further Removal of Factor V Related Antigen From Bovine Thrombin by Utilizing a Membrane-Filtration Step
Clinical and Applied Thrombosis/Hemostasis, April 1, 2008; 14(2): 135 - 140.
[Abstract] [PDF]

Home page
 CLIN APPL THROMB HEMOSTHome page
S. Haas
The Use of a Surgical Patch Coated With Human Coagulation Factors in Surgical Routine: A Multicenter Postauthorization Surveillance
Clinical and Applied Thrombosis/Hemostasis, October 1, 2006; 12(4): 445 - 450.
[Abstract] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
ANN THORAC SURG ASIAN CARDIOVASC THORAC ANN EUR J CARDIOTHORAC SURG
J THORAC CARDIOVASC SURG ICVTS ALL CTSNet JOURNALS
Copyright © 2005 by The Society of Thoracic Surgeons.