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Right arrow Lung - cancer

Ann Thorac Surg 2005;79:438-442
© 2005 The Society of Thoracic Surgeons

Original article: General thoracic

Immediate and Long-Term Survival After Surgery for Lung Cancer in Heart Transplant Recipients

Patrick Bagan, MD*, Jalal Assouad, MD, Pascal Berna, MD, Redha Souilamas, MD, Françoise Le Pimpec Barthes, MD, Marc Riquet, MD

Department of Thoracic Surgery, Georges Pompidou European Hospital, Paris V University, Paris, France

Accepted for publication July 14, 2004.

* Address reprint requests to Dr Bagan, Service de Chirurgie Thoracique, Hôpital Européen Georges Pompidou, 20-40 rue Leblanc, 75908 Paris, France (E-mail: patrick.bagan{at}hop.egp.ap-hop-paris.fr).

BACKGROUND: Lung cancer observed after heart transplantation is considered to have a poor prognosis. However, the results of surgical treatment have not yet been significantly evaluated. This retrospective study analyzed the immediate and long-term results after surgery.

METHODS: From May 1990 to December 2003, 25 heart transplant recipients underwent surgery for lung cancer. There were 22 men and 3 women, the mean age was 60.7 years (49–72). All patients had a smoking history. Lung tumors were discovered by routine chest roentgenograms and computed tomography scans in 17 patients (68%), because of clinical symptoms in 7 (28%), and incidentally in 1 (4%). The surgical procedures consisted of 23 lobectomies and 2 wedge resections.

RESULTS: The mean postoperative hospital stay was 14.2 days (5–34). The morbidity rate was 28% (n = 7 patients). The mortality rate was 12% patients (n = 3 patients). The postoperative complications in 7 of 10 patients were mainly from infectious origin. Five-year survival rate was 40.9% with a median survival of 45 months. Seven patients died during follow-up (3 from cancer and 4 from other diseases). Significant better survival was observed in N0 patients than in N+ patients (median survival of 56.8 months in N0 vs 13.5 months in N+ patients (p = 0.017).

CONCLUSIONS: Long-term results after surgery were satisfactory in early stage disease, despite a high risk for postoperative infection. Our results underline the efficiency of a close follow-up for transplant recipients with a smoking history, leading to cancer detection at an early stage.




This article has been cited by other articles:


Home page
 Ann. Thorac. Surg.Home page
P. Bagan, F. L. P. Barthes, and M. Riquet
Prognosis of Lung Cancer in Heart Transplant Recipient
Ann. Thorac. Surg., January 1, 2006; 81(1): 409 - 409.
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