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Ann Thorac Surg 2005;79:426-432
© 2005 The Society of Thoracic Surgeons

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Original article: General thoracic

Inflammatory Pseudotumor of the Lung in Adults

^a Department of Thoracic Surgery
^b Department of Pathology, Scientific Institute H San Raffaele
^c Department of Thoracic Surgery, Niguarda Ca' Granda Hospital, Milan, Italy
^d Department of Pathology, Niguarda Ca' Granda Hospital, Milan, Italy

Accepted for publication July 23, 2004.

^* Address reprint requests to Dr Melloni, Unità Operativa di Chirurgia Toracica, Ospedale San Raffaele, Via Olgettina, 60, 20132, Milan, Italy (E-mail: giulio.melloni{at}hsr.it).

BACKGROUND: Thoracic surgeons have limited experience of inflammatory pseudotumors of the lung owing to their rare occurrence in routine clinical practice.

METHODS: We retrospectively investigated the clinicopathologic features of 18 patients with inflammatory pseudotumor of the lung observed between 1992 and 2002.

RESULTS: There were 13 men and 5 women. Median age was 57 years. Eight patients (44%) were symptomatic. Computed tomographic scan showed a solitary nodule (3 cm) in 12 patients, bilateral nodules in 1, and a mass in 5. Two patients had undergone prior incomplete resections. Lobectomy was performed in 5 patients, bilobectomy in 1, segmentectomy in 1, and wedge resection in 11. Complete resection was achieved in 13 patients (72%). There was no operative mortality. Follow-up was complete in all patients (range, 13 to 134 months; median, 63 months). Overall 3-year and 5-year survival rates were 82% and 74%, respectively. Thirteen patients are currently alive with no evidence of disease, 1 is alive with disease, 1 died of unrelated causes, and 3 had a relapse and died. Completeness of resection and lesion size less than or equal to 3 cm were associated with a better survival (p < 0.001 and p = 0.007, respectively). Multivariate Cox analysis confirmed the association between completeness of resection and better survival, which is independent of other clinicopathologic variables (p = 0.02).

CONCLUSIONS: This series shows that a significant number of patients with inflammatory pseudotumor of the lung have a poor prognosis and confirms the need for radical resection in the treatment of this unusual entity.

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