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Ann Thorac Surg 2005;79:375-382
© 2005 The Society of Thoracic Surgeons
a Department of Cardiothoracic Surgery, Rotterdam, The Netherlands
b Department of Epidemiology and Biostatistics, Erasmus MC, Rotterdam, The Netherlands
* Address reprint requests to Dr Kappetein, Department of Cardiothoracic Surgery, Room BD 156, Erasmus Medical Center Rotterdam, PO Box 2040, Rotterdam 3000 CA, the Netherlands (E-mail: a.kappetein{at}erasmusmc.nl).
A systematic review was undertaken to select studies that compared the accuracy of 2-[18F]-fluoro-2-deoxy-D-glucose positron emission tomography with computed tomographic imaging in detecting mediastinal lymph node metastases in patients with nonsmall cell lung cancer. Two authors selected relevant articles according to predefined criteria. With a meta-analytic method, summary receiver operating characteristic curves were constructed. The point on the receiver operating characteristic curve with equal sensitivity and specificity for 2-[18F]-fluoro-2-deoxy-D-glucose positron emission tomography was Q* = 0.90 (95% confidence interval [CI], 0.86 to 0.95). For computed tomography it was 0.70 (95% CI, 0.65 to 0.75). The difference was highly significant (p < 0.0001). We conclude that 2-[18F]-fluoro-2-deoxy-D-glucose positron emission tomography is more accurate than computed tomography in detecting mediastinal lymph node metastases.
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