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Ann Thorac Surg 2005;79:334-336
© 2005 The Society of Thoracic Surgeons

Case report

Delayed Thrombin Generation With Hirudin Anticoagulation During Prolonged Cardiopulmonary Bypass

Fraser D. Rubens, MD, MSa,*, Gilbert Lavaleeb, Marc A. Ruel, MD, MPHa, Thierry Mesana, MD, PhDa, Michael Bourke, MDc

a Division of Cardiac Surgery, Ottawa, Ontario, Canada
b Division of Perfusion, Ottawa, Ontario, Canada
c Division of Cardiac Anaesthesia, University of Ottawa Heart Institute, Ottawa, Ontario, Canada

Accepted for publication August 12, 2003.

* Address reprint requests to Dr Rubens, Ottawa Heart Institute, 40 Ruskin St, Ottawa, Ontario K1Y 4W7, Canada
frubens{at}ottawaheart.ca

Patients with heparin-induced thrombocytopenia requiring urgent cardiac surgery present a unique challenge that must be addressed by the use of nonheparin alternatives for anticoagulation during cardiopulmonary bypass. Although isolated cases have been presented involving the use of antithrombin III independent thrombin inhibitor hirudin in this situation, its ability to completely inhibit thrombin activity has not been demonstrated. In this report we describe the efficacy of this drug in inhibiting thrombin during a case requiring prolonged cardiopulmonary bypass.




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Home page
 PerfusionHome page
D Belway, F D Rubens, B Henley, A Babaev, and T Mesana
Delayed thrombin generation is not associated with fibrinopeptide formation during prolonged cardiopulmonary bypass with hirudin anticoagulation
Perfusion, September 1, 2006; 21(5): 259 - 262.
[Abstract] [PDF]


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