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Ann Thorac Surg 2005;79:318-322
© 2005 The Society of Thoracic Surgeons

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New technology

The Acute Effects of Transthoracic Cryoablation on Normal Lung Evaluated in a Porcine Model

^a Department of Surgery, Division of General Thoracic Surgery, School of Medicine, Keio University, Tokyo, Japan
^b Department of Pathology, School of Medicine, Keio University, Tokyo, Japan

Accepted for publication September 10, 2003.

^* Address reprint requests to Dr Izumi, Division of General Thoracic Surgery, Department of Surgery, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan
yotaro{at}sc.itc.keio.ac.jp

PURPOSE: Percutaneous transthoracic cryoablation of lung parenchymal tumors offers a potentially less invasive alternative to thoracoscopic tumor resection. In the present study, we investigated the feasibility of transthoracic cryoprobe insertion into the lung parenchyma.

DESCRIPTION: Cryoablation was performed in porcine lung through a thoracotomy. A 2-mm diameter cryoprobe was inserted to a depth of 3 cm from the pleura. Cryoablation was performed as one or two cycles of 15-minute freeze followed by 5-minute thaw. Bleeding time and amount, and air leakage pressure from the insertion site was measured and compared between cycles.

EVALUATION: The bleeding time and amount significantly increased, and air leakage pressure significantly decreased with two cycles of cryoablation compared with one cycle. Histologically, the primary finding in the cryolesion was localized pulmonary hemorrhage.

CONCLUSIONS: Bleeding time, bleeding amount, and air leakage from the insertion site after two cycles (453 ± 202 s, 1.3 ± 0.6 g, and 28 ± 12 cm H₂O, resectively) were considered unlikely to cause acute serious complications. Although long-term studies are needed, the present study provides support for transthoracic cryoablation.

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Joseph B. Shrager
Ann. Thorac. Surg. 2005 79: 322. [Extract] [Full Text] [PDF]

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