| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Ann Thorac Surg 2004;78:1312-1318
© 2004 The Society of Thoracic Surgeons
a Department of Cardiac Surgery, University Hospital Ulm, Ulm, Germany
b Division of Nephrology, University Hospital Ulm, Ulm, Germany
c Department of Cardiology, University Hospital Ulm, Ulm, Germany
d Department of Cardiology, University Hospital Maastricht, Maastricht, the Netherlands
Accepted for publication February 18, 2004.
* Address reprint requests to Dr Stracke, Division of Nephrology, University Hospital of Ulm, Robert-Koch Str 8, 89081 Ulm, Germany
sylvia.stracke{at}medizin.uni-ulm.de
BACKGROUND: The development of fibromuscular intimal hyperplasia and subsequent graft failure remains an urgent problem in cardiac surgery. Transforming growth factor-ß1 (TGF-ß1) is involved in the pathogenesis of arteriosclerosis through induction of extracellular matrix proteins. We tested the hypothesis that intimal hyperplasia is already present in human saphenous veins and left internal mammary arteries before coronary artery bypass surgery and is associated with an increased expression of TGF-ß1.
METHODS: Forty-six segments of saphenous veins and 27 of left internal mammary arteries were collected from 50 patients undergoing coronary artery bypass surgery. Morphometric analysis was performed by microscopic computer analysis. Immunohistochemistry was performed with antibodies directed against TGF-ß1, its latent binding protein (LTBP-1) and its type 2 receptor (RII).
RESULTS: The incidence of intimal hyperplasia was significantly higher in saphenous veins (67.4%) than in mammary arteries (29.6%; p < 0.05). Saphenous veins and mammary arteries with intimal hyperplasia expressed more TGF-ß1 (endothelial and intimal layers) and LTBP-1 (intimal and medial layers) when compared with corresponding vessels without hyperplasia (both groups p < 0.05). Endothelial and intimal RII expression was significantly higher in saphenous veins with intimal hyperplasia as compared with saphenous veins without hyperplasia (p < 0.05). Transforming growth factor-ß1 staining in the intima correlated with the presence of an intimal hyperplasia in saphenous veins (
= 0.317) and mammary arteries ( = 0.428).
CONCLUSIONS: Local TGF-ß1 expression is associated with the presence of intimal hyperplasia in the examined vessels. Preexisting intimal hyperplasia is more prevalent and serious in saphenous veins than in left internal mammary arteries, giving further explanation to the superior long-term results of left internal mammary grafts.
This article has been cited by other articles:
|
|
 |
|
  B. Beghe, E. Bazzan, S. Baraldo, F. Calabrese, F. Rea, M. Loy, P. Maestrelli, R. Zuin, L. M. Fabbri, and M. Saetta Transforming growth factor-{beta} type II receptor in pulmonary arteries of patients with very severe COPD Eur. Respir. J., September 1, 2006; 28(3): 556 - 562. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. S.R. Souza, B. Johansson, L. Bojo, R. Karlsson, H. Geijer, D. Filbey, L. Bodin, M. Arbeus, and M. R. Dashwood Harvesting the saphenous vein with surrounding tissue for CABG provides long-term graft patency comparable to the left internal thoracic artery: Results of a randomized longitudinal trial. J. Thorac. Cardiovasc. Surg., August 1, 2006; 132(2): 373 - 378.e5. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. van den Boom, M. Sarbia, K. von Wnuck Lipinski, P. Mann, J. Meyer-Kirchrath, B.H. Rauch, K. Grabitz, B. Levkau, K. Schror, and J.W. Fischer Differential Regulation of Hyaluronic Acid Synthase Isoforms in Human Saphenous Vein Smooth Muscle Cells: Possible Implications for Vein Graft Stenosis Circ. Res., January 6, 2006; 98(1): 36 - 44. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| ANN THORAC SURG | ASIAN CARDIOVASC THORAC ANN | EUR J CARDIOTHORAC SURG |
| J THORAC CARDIOVASC SURG | ICVTS | ALL CTSNet JOURNALS |
