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Ann Thorac Surg 2004;78:e41-e42
© 2004 The Society of Thoracic Surgeons

Case report

Pericardial synovial sarcoma: 14-year survival with multimodality therapy

Gerry Van der Mieren, MDa, Stefan Willems, MDb, Raf Sciot, MD, PhDb, Herlinde Dumez, MDc, Allan Van Oosterom, MD, PhDc, Willem Flameng, MD, PhDa, Paul Herijgers, MD, PhDa,*

a Department of Cardiac Surgery, Leuven, Belgium
b Department of Pathology, Leuven, Belgium
c Department of Medical Oncology, Katholieke Universiteit Leuven, Leuven, Belgium

Accepted for publication February 3, 2004.

* Address reprint requests to Dr Herijgers, Department of Cardiac Surgery, K. U. Leuven, U. Z. Herestraat 49, Leuven B-3000, Belgium
paul.herijgers{at}med.kuleuven.ac.be

We report a case of recurrent primary synovial sarcoma of the pericardium. Reverse transcriptase-polymerase chain reaction analysis for t(X,18) demonstrated the presence of the chimeric transcript SYT/SSX. Because of the rarity of this entity, optimal therapy is unknown. The prognosis of this tumor is very poor in previous reports. In this report, we present a case with five recurrences treated by a combination of surgery, chemotherapy, and radiotherapy. The patient survives now for more than 14 years, the longest reported survival of a primary synovial sarcoma of the pericardium.






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