ATS
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Personal Folders
Right arrow Download to citation manager
Right arrow Author home page(s):
Mark W. Turrentine
Yousuf Mahomed
John W. Brown
Daniel R. Meldrum
Right arrow Permission Requests
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Tsai, B. M.
Right arrow Articles by Meldrum, D. R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Tsai, B. M.
Right arrow Articles by Meldrum, D. R.
Related Collections
Right arrow Lung - basic science

Ann Thorac Surg 2004;78:360-368
© 2004 The Society of Thoracic Surgeons

Review

Hypoxic pulmonary vasoconstriction in cardiothoracic surgery: basic mechanisms to potential therapies

Ben M. Tsai, MDa, Meijing Wang, MDa,c, Mark W. Turrentine, MDa, Yousuf Mahomed, MDa, John W. Brown, MDa, Daniel R. Meldrum, MDa,b,c*

a Section of Cardiothoracic Surgery, Department of Surgery, Indianapolis, Indiana, USA
b Department of Physiology, Indiana University School of Medicine, Indianapolis, Indiana, USA
c Indiana Center for Vascular Biology and Medicine, Indianapolis, Indiana, USA

* Address reprint requests to Dr Meldrum, 545 Barnhill Dr, Emerson Hall 215, Indianapolis, IN, USA 46202
e-mail: dmeldrum{at}iupui.edu

Hypoxic pulmonary vasoconstriction is postulated to be an adaptive mechanism to match lung perfusion with ventilation; however, the consequences of the maladaptive effects of pulmonary vasoconstriction represent formidable therapeutic challenges. Understanding the basic mechanisms of hypoxic pulmonary vasoconstriction will enhance the assimilation of translational research into clinical practice. The purposes of this review are to (1) define basic mechanisms of pulmonary vasoconstriction and vasorelaxation; (2) delineate the biphasic contractile response to hypoxia; (3) critically examine data that support the mediator hypothesis versus the ion channel hypothesis; and (4) explore potential mechanistic-based therapies for hypoxic pulmonary vasoconstriction.




This article has been cited by other articles:


Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
T. Lahm, K. M. Patel, P. R. Crisostomo, T. A. Markel, M. Wang, C. Herring, and D. R. Meldrum
Endogenous estrogen attenuates pulmonary artery vasoreactivity and acute hypoxic pulmonary vasoconstriction: the effects of sex and menstrual cycle
Am J Physiol Endocrinol Metab, September 1, 2007; 293(3): E865 - E871.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
O. A. Minai, C. M. Pandya, J. A. Golish, J. F. Avecillas, K. McCarthy, S. Marlow, and A. C. Arroliga
Predictors of Nocturnal Oxygen Desaturation in Pulmonary Arterial Hypertension
Chest, January 1, 2007; 131(1): 109 - 117.
[Abstract] [Full Text] [PDF]

Home page
 Anesth. Analg.Home page
A. D. Maslow, G. Stearns, P. Batula, C. S. Schwartz, J. Gough, and A. K. Singh
The hemodynamic effects of methylene blue when administered at the onset of cardiopulmonary bypass.
Anesth. Analg., July 1, 2006; 103(1): 2 - 8.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
S. Jaillard, B. Larrue, P. Deruelle, A. Delelis, T. Rakza, G. Butrous, and L. Storme
Effects of Phosphodiesterase 5 Inhibitor on Pulmonary Vascular Reactivity in the Fetal Lamb.
Ann. Thorac. Surg., March 1, 2006; 81(3): 935 - 942.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
B. M. Tsai, M. W. Turrentine, B. C. Sheridan, M. Wang, A. C. Fiore, J. W. Brown, and D. R. Meldrum
Differential Effects of Phosphodiesterase-5 Inhibitors on Hypoxic Pulmonary Vasoconstriction and Pulmonary Artery Cytokine Expression
Ann. Thorac. Surg., January 1, 2006; 81(1): 272 - 278.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
B. M. Tsai, M. Wang, J. M. Pitcher, K. K. Meldrum, and D. R. Meldrum
Hypoxic pulmonary vasoconstriction and pulmonary artery tissue cytokine expression are mediated by protein kinase C
Am J Physiol Lung Cell Mol Physiol, December 1, 2004; 287(6): L1215 - L1219.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
B. M. Tsai, M. Wang, M. Clauss, P. Sun, and D. R. Meldrum
Endothelial monocyte-activating polypeptide II causes NOS-dependent pulmonary artery vasodilation: a novel effect for a proinflammatory cytokine
Am J Physiol Regulatory Integrative Comp Physiol, October 1, 2004; 287(4): R767 - R771.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
ANN THORAC SURG ASIAN CARDIOVASC THORAC ANN EUR J CARDIOTHORAC SURG
J THORAC CARDIOVASC SURG ICVTS ALL CTSNet JOURNALS
Copyright © 2004 by The Society of Thoracic Surgeons.