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Ann Thorac Surg 2004;77:2177-2181
© 2004 The Society of Thoracic Surgeons

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New technology

Bovine glue (BioGlue) is catabolized by enzymatic reaction in the vascular dog model

^a Heart Centre University Hospital Ghent, Ghent, Belgium
^b Department of Pathology, University Hospital Ghent, Ghent, Belgium

Accepted for publication May 8, 2003.

^* Address reprint requests to Dr Van Nooten, Cardiac Surgery Department 5K12, University Hospital Ghent, De Pintelaan 185, 9000 Ghent, Belgium.
e-mail: guido.vannooten{at}rug.ac.be

Abstract

PURPOSE: The aim of the study is to explore the feasibility, patency, and histologic changes of a sutureless vascular anastomotic technique using biological glue as sole fixation method.

DESCRIPTION: Eight mongrel dogs (±15 kg) underwent direct reanastomosis of their transsected iliac arteries. Both ends were placed on a 5-mm balloon and the anastomosis was secured with biological glue (BioGlue, Cryolife, Kennesaw, GA). No intravascular suture material was used. All survivors were angiographically controlled for patency after 6 weeks and 3 months. Then the animals were euthanized and tissues were obtained for histologic and pathologic examination by light and electron microscopy.

EVALUATION: All procedures were successful except for 1 animal that died of uncontrollable bleeding at the anastomotic site. All first-time angiographically controlled grafts except three were patent. One animal showed manifest signs of fungal infection. Histology detected early granulocyte infiltration with an important enzymatic reaction adjacent to the surface of glue. Later on, the glue gradually regressed to disappear completely. Fibroblastic neointimal lining was noticed in most of the anastomoses, with some marked differences in the endothelium compared with normal.

CONCLUSIONS: Good permeability (57%) was observed in this new sutureless anastomotic technique in the canine model. In contrast to previous reported studies we noticed a clear enzymatic breakdown of the glue before total disappearance. It is not yet known to what extend use of the bovine glue was responsible for this phenomenon.

This article has been cited by other articles:

				W. Schiller, H. Rudorf, C. B. Welzel, M. J. Kiderlen, C. Probst, O. Dewald, and A. Welz Sutureless anastomoses of rabbit carotid arteries with BioGlue. J. Thorac. Cardiovasc. Surg., December 1, 2007; 134(6): 1513 - 1518. [Abstract] [Full Text] [PDF]

				G. J. Van Nooten, P. Somers, R. Forsyth, K. Narine, Y. Van Belleghem, S. Jacobs, and F. De Somer Autologous glue: Part of the sticky mystery unraveled J. Thorac. Cardiovasc. Surg., August 1, 2007; 134(2): 415 - 423. [Abstract] [Full Text] [PDF]