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Ann Thorac Surg 2004;77:2021-2028
© 2004 The Society of Thoracic Surgeons
a Department of Cardiac Surgery, "GM Lancisi" Hospital, Ancona, Italy
b Department of Cardiopulmonary Surgery, St Antonius Hospital, Nieuwegein, The Netherlands
c First Department of Surgery, Hamamatsu University School of Medicine, Hamamatsu, Japan
d Department of Cardiac Surgery, Policlinico S Orsola, University of Bologna, Bologna, Italy
Accepted for publication October 28, 2003.
* Address reprint requests to Dr Di Eusanio, Dipartimento di Cardiochirurgia, Ospedale "GM Lancisi," Via Conca 71, 60020, Torrette-Ancona, Italy.
e-mail: m_dieus{at}hotmail.com
BACKGROUND: This study compares the results of the separated graft technique and the en bloc technique as a method of arch vessels reimplantation during surgery of the aortic arch and determines the predictive risk factors associated with hospital mortality and adverse neurologic outcome during aortic arch repair.
METHODS: Between October 1995 and March 2002, 352 patients (mean age 64.9 ± 11.3 years; urgent status: 49/352 [13.9%]) underwent surgery of the aortic arch using the separated graft technique (group A: n = 230 [65.3%]) and the en bloc technique (group B: n = 122 [34.7%]) to reimplant the arch vessels. An aortic arch replacement was performed in 32 patients (9.1%), an ascending aorta and arch replacement in 222 patients (53.1%), an aortic arch and descending aorta replacement in 16 patients (4.5%), and a complete replacement of the thoracic aorta in 82 patients (23.3%). Brain protection was achieved by means of antegrade selective cerebral perfusion in all patients. The mean cardiopulmonary bypass time was 204.8 ± 61.9 minutes (group A: 199.7 ± 57.0 minutes; group B: 214.5 ± 69.4 minutes; p = 0.033), the mean myocardial ischemic time was 121.5 ± 43.2 minutes (group A: 116.7 ± 38.9 minutes; group B: 130.80 ± 49.4 minutes; p = 0.003), and the mean antegrade selective cerebral perfusion time was 84.5 ± 36.4 (group A: separated graft technique 91.3 ± 36.3 minutes; group B: 70.6 ± 32.7 minutes; p = 0.000).
RESULTS: Overall hospital mortality was 6.8% (group A: 6.5%; group B: 7.4%; p = not significant [NS]). The permanent neurologic dysfunction rate was 3.5% (group A: 4.0%; group B: 2.5%; p = NS). The transient neurologic dysfunction rate was 5.4% (group A: 5.5%; group B: 5.2%, p = NS). Postoperative systemic morbidity was similar in the two groups. A logistic regression analysis revealed preoperative cardiac tamponade (p = 0.011; odds ratio [OR] = 5.9) and cardiopulmonary bypass time (p = 0.010; OR = 1.01/min) to be independent predictors of hospital mortality. None of the analyzed preoperative variables were associated with an increased risk of permanent neurologic dysfunction. Age more than 70 years old (p = 0.029, OR = 5.7), myocardial revascularization (p = 0.001, OR = 2.9), and pump time (p = 0.013, OR = 1.01/min) were indicated as independent predictors of transient neurologic dysfunction by logistic regression.
CONCLUSIONS: Antegrade selective cerebral perfusion was confirmed to be a safe method of cerebral protection allowing complex aortic arch operations to be performed with acceptable results in terms of hospital mortality and neurologic outcome. The separated graft technique had no adverse impact on hospital mortality and morbidity.
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