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Ann Thorac Surg 2004;77:1630-1634
© 2004 The Society of Thoracic Surgeons

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Original article: cardiovascular

Neurocognitive outcome after retrograde cerebral perfusion

^a Department of Cardiothoracic Surgery, University of Tokyo, Tokyo, Japan
^b School Education Center, University of Tsukuba, Tokyo, Japan
^c Department of Public Health, University of Tokyo, Tokyo, Japan

Accepted for publication October 2, 2003.

^* Address reprint requests to Dr Miyairi, Department of Cardiovascular Surgery, Mitsui Memorial Hospital, 1 Kandaizumicho Chiyodaku, Tokyo 101-8643, Japan
e-mail: tmiyairi-tky{at}umin.ac.jp

BACKGROUND: Neurocognitive outcome in patients undergoing thoracic aortic surgery using retrograde cerebral perfusion (RCP) remains uncertain.

METHODS: Forty-two patients undergoing thoracic aortic surgery using RCP were enrolled in the study. The patients' neurocognitive state was assessed by the revised Wechsler Adult Intelligence Scale (WAIS-R) a few days before operation, at 2 to 3 weeks, and at 4 to 6 months after operation.

RESULTS: There were no stroke, seizure, and hospital death. Significant performance deterioration was observed in digit span, arithmetic, and picture completion of the WAIS-R subtests. Bivariate comparison showed that older age (late vocabulary, late similarities, and late object assembly), longer RCP time (early picture arrangement, and early block design), later awake time (early and late picture arrangement, and early block design), longer respirator use (early and late digit span, late picture arrangement), longer ICU time (late picture completion, early and late picture arrangement, and early block design), and longer hospital stay (early picture arrangement) were significantly associated with the decline in neurocognitive performance. Stepwise logistic regression analysis disclosed that older age (late similarities and late object assembly), later awake time (late picture arrangement), and longer respirator use (early and late digit span, and late picture arrangement) were most predictive for the decline in neurocognitive performance.

CONCLUSIONS: On average, digit span, arithmetic, and picture completion tests were most sensitive in detecting the decline in neurocognitive performance. The relationship between the duration of RCP and neurocognitive test results was not significant.

This article has been cited by other articles:

				T. Miyairi, S. Takamoto, Y. Kotsuka, A. Takeuchi, K. Yamanaka, and H. Sato Comparison of neurocognitive results after coronary artery bypass grafting and thoracic aortic surgery using retrograde cerebral perfusion Eur. J. Cardiothorac. Surg., July 1, 2005; 28(1): 97 - 101. [Abstract] [Full Text] [PDF]