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Ann Thorac Surg 2004;77:903-907
© 2004 The Society of Thoracic Surgeons

Original article: cardiovascular

Morphometry of coronary capillaries in hypoplastic left heart syndrome

Caner Salih, MB, ChB, FRCSa, Mary N. Sheppard, MD, FRCPathb, Siew Yen Ho, PhD, FRCPatha*

a Departments of Pediatrics and Histopathology, Imperial College, London, United Kingdom
b Royal Brompton and Harefield NHS Trust, London, United Kingdom

Accepted for publication July 10, 2003.

* Address reprint requests to Dr Ho, Department of Paediatrics, Faculty of Medicine, Imperial College, National Heart & Lung Institute, Dovehouse St, London SW3 6LY, UK
e-mail: yen.ho{at}imperial.ac.uk

BACKGROUND: Hypoplastic left heart syndrome is a condition characterized by a constellation of morphological malformations affecting the left side of the heart. We studied the capillary network, and quantified the capillarization of the ventricular myocardium, which, if different from normal, may have implications for the success of surgical reconstruction.

METHODS: The capillaries were detected by immunohistochemistry using a monoclonal antibody (von Willebrand's factor) against the endothelium. Hearts with hypoplastic left heart syndrome have higher mean and maximal diffusion distances from any arbitrary point to the nearest capillary than normal hearts.

RESULTS: There was no significant difference in the heterogeneity of capillary distribution between the hearts with hypoplastic left heart syndrome and the control heart. Increase in distance was found in both the right and left ventricles.

CONCLUSIONS: Hearts with hypoplastic left heart syndrome show a reduction in the capillarization of both the right and left ventricles compared with age-matched controls. We believe this may be an inherent abnormality of hypoplastic left heart syndrome that may have implications for ventricular development.




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[Abstract] [Full Text] [PDF]


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