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Juan C. Chachques
Christophe Acar
Jesus Herreros
Jean-Noel Fabiani
Alain F. Carpentier
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Ann Thorac Surg 2004;77:1121-1130
© 2004 The Society of Thoracic Surgeons

Review

Cellular cardiomyoplasty: clinical application

Juan C. Chachques, MD, PhDa*, Christophe Acar, MDa, Jesus Herreros, MDa, Jorge C. Trainini, MDa, Felipe Prosper, MDa, Nicola D'Attellis, MDa, Jean-Noel Fabiani, MDa, Alain F. Carpentier, MD, PhDa

a Department of Cardiovascular Surgery, European Hospital Georges Pompidou, University of Paris, Paris, France

* Address reprint requests to Dr Chachques, Department of Cardiovascular Surgery, European Hospital Georges Pompidou, 20 rue Leblanc, 75015 Paris, France
e-mail: j.chachques{at}brs.ap-hop-paris.fr

Myocardial regeneration can be induced with the implantation of a variety of myogenic and angiogenic cell types. More than 150 patients have been treated with cellular cardiomyoplasty worldwide, 18 patients have been treated by our group. Cellular cardiomyoplasty seems to reduce the size and fibrosis of infarct scars, limit postischemic remodelling, and restore regional myocardial contractility. Techniques for skeletal myoblasts culture and ex vivo expansion using autologous patient serum (obtained from plasmapheresis) have been developed by our group. In this article we propose (1) a total autologous cell culture technique and procedures for cell delivery and (2) a clinical trial with appropriate endpoints structured to determine the efficacy of cellular cardiomyoplasty.




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