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Right arrow Transplantation - heart

Ann Thorac Surg 2004;77:363-371
© 2004 The Society of Thoracic Surgeons

Review

Drug immunosuppression therapy for adult heart transplantation. Part 2: clinical applications and results

Xavier M. Mueller, MDa*

a Department of Cardiovascular Surgery, Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke, Quebec, Canada

* Address reprint requests to Dr Mueller, Department of Cardiovascular Surgery, Centre Hospitalier Universitaire de Sherbrooke, 3001, 12e Avenue Nord, Sherbrooke, Quebec J1H 5N4, Canada
e-mail: xavier.mueller{at}usherbrooke.ca

This review describes the clinical application of classical immunosuppressive drugs as well as that of more recent drugs. All current immunosuppressive drugs target T-cell activation, and cytokine production and clonal expansion, or both. Immunosuppressive protocols can be broadly divided into induction therapy, maintenance immunosuppression, and treatment of acute rejection episodes.






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Copyright © 2004 by The Society of Thoracic Surgeons.